{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T09:45:36Z","timestamp":1725875136272},"reference-count":0,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1975,2,1]],"date-time":"1975-02-01T00:00:00Z","timestamp":160444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1975,2]]},"abstract":"<jats:p>\n            The in vitro activity of cefazolin was assessed by continuous turbidimetric monitoring of cultures of gram-negative bacilli and the results were compared with those previously obtained with other beta-lactam agents using the same strains and methods. Cefazolin was found to induce rapid lysis of ampicillin-susceptible and -resistant strains of\n            <jats:italic>Escherichia coli<\/jats:italic>\n            at a lower concentration than any other beta-lactam agent tested; its stability to beta-lactamase, as judged by regrowth studies, was generally considerably greater than that of other antibiotics of this group. Tested against 103 ampicillin-resistant enterobacteria, cefazolin was found to be more active than cephalothin against\n            <jats:italic>E. coli<\/jats:italic>\n            , but no systematic increase in susceptibility to cefazolin was seen with other species. A study of cefazolin in an in vitro model which simulates the hydrokinetic features of the urinary bladder showed it to be as active as ampicillin against ampicillin-susceptible\n            <jats:italic>E. coli<\/jats:italic>\n            and as active as cephalothin against ampicillin-resistant\n            <jats:italic>E. coli<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.7.2.191","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"191-195","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Activity of Cefazolin Against Dense Populations of Enterobacteria"],"prefix":"10.1128","volume":"7","author":[{"given":"D.","family":"Greenwood","sequence":"first","affiliation":[{"name":"Department of Bacteriology, St. Bartholomew's Hospital, London EC1A 7BE England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H.","family":"Chan-Teoh","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, St. Bartholomew's Hospital, London EC1A 7BE England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"O'Grady","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, St. Bartholomew's Hospital, London EC1A 7BE England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.7.2.191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.7.2.191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T13:50:57Z","timestamp":1645451457000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.7.2.191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1975,2]]}},"alternative-id":["10.1128\/AAC.7.2.191"],"URL":"https:\/\/doi.org\/10.1128\/aac.7.2.191","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,2]]},"assertion":[{"value":"1975-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}