{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T19:09:34Z","timestamp":1760987374806},"reference-count":0,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1975,4,1]],"date-time":"1975-04-01T00:00:00Z","timestamp":165542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1975,4]]},"abstract":"<jats:p>\n            Most ampicillin-resistant\n            <jats:italic>Shigella<\/jats:italic>\n            are susceptible to cephalexin. Randomized treatment with cephalexin or ampicillin was given to 154 infants and children with acute diarrhea. Rectal swab cultures revealed\n            <jats:italic>Shigella<\/jats:italic>\n            in 42%,\n            <jats:italic>Salmonella<\/jats:italic>\n            in 6%, enteropathogenic\n            <jats:italic>Escherichia coli<\/jats:italic>\n            in 2%, and no pathogen in 50%. Cephalexin failed to eradicate\n            <jats:italic>Shigella<\/jats:italic>\n            after 5 days of treatment in 76% of patients as contrasted with 28% of ampicillin-treated patients with susceptible organisms.\n            <jats:italic>Shigella<\/jats:italic>\n            persisted in 78% of ampicillin-treated patients with resistant organisms. Diarrhea lasted more than 5 days in 43% of cephalexin-treated patients, in 56% of the ampicillin group with resistant organisms, but in only 9% of ampicillin-treated patients with susceptible organisms. The failure of cephalexin was due to the relatively high minimal inhibitory concentrations and minimal bacterial concentrations of 5 or 10 \u03bcg\/ml and, although serum concentrations were twice the minimal bacterial concentration, they were not sufficient to demonstrate killing by the serum dilution method. In vitro susceptibility or resistance of\n            <jats:italic>Shigella<\/jats:italic>\n            to ampicillin correlated with clinical success or failure. Cephalexin is not a suitable drug for treatment of shigellosis in patients with ampicillin-resistant organisms.\n          <\/jats:p>","DOI":"10.1128\/aac.7.4.415","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"415-420","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Comparative Efficacy of Cephalexin and Ampicillin for Shigellosis and Other Types of Acute Diarrhea in Infants and Children"],"prefix":"10.1128","volume":"7","author":[{"given":"John D.","family":"Nelson","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas, Texas 75235"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth C.","family":"Haltalin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas, Texas 75235"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.7.4.415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.7.4.415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T13:14:03Z","timestamp":1645449243000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.7.4.415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1975,4]]}},"alternative-id":["10.1128\/AAC.7.4.415"],"URL":"https:\/\/doi.org\/10.1128\/aac.7.4.415","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,4]]},"assertion":[{"value":"1975-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}