{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:15:42Z","timestamp":1781180142742,"version":"3.54.1"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1975,5,1]],"date-time":"1975-05-01T00:00:00Z","timestamp":168134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1975,5]]},"abstract":"<jats:p>\n            A mixed infection of\n            <jats:italic>Bacteroides fragilis<\/jats:italic>\n            and\n            <jats:italic>Fusobacterium necrophorum<\/jats:italic>\n            was resistant to treatment with penicillin even though a pure\n            <jats:italic>F. necrophorum<\/jats:italic>\n            infection could be successfully treated with penicillin. Since\n            <jats:italic>B. fragilis<\/jats:italic>\n            alone did not produce infection, these results indicate that\n            <jats:italic>B. fragilis<\/jats:italic>\n            can protect\n            <jats:italic>F. necrophorum<\/jats:italic>\n            from penicillin in vivo. The extent of protection afforded by a strain of\n            <jats:italic>B. fragilis<\/jats:italic>\n            was related to its level of resistance to penicillin. Only a few cells of\n            <jats:italic>B. fragilis<\/jats:italic>\n            were required in the initial bacterial injection. Moreover, protection was demonstrated when\n            <jats:italic>B. fragilis<\/jats:italic>\n            cells were injected as late as 24 h after the\n            <jats:italic>F. necrophorum<\/jats:italic>\n            cells. Protection of\n            <jats:italic>F. necrophorum<\/jats:italic>\n            from penicillin by\n            <jats:italic>B. fragilis<\/jats:italic>\n            was also demonstrated in vitro.\n          <\/jats:p>","DOI":"10.1128\/aac.7.5.698","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"698-703","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":52,"title":["In Vivo Protection of\n            <i>Fusobacterium necrophorum<\/i>\n            from Penicillin by\n            <i>Bacteroides fragilis<\/i>"],"prefix":"10.1128","volume":"7","author":[{"given":"A. S.","family":"Hackman","sequence":"first","affiliation":[{"name":"Anaerobe Laboratory, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. D.","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Anaerobe Laboratory, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.7.5.698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.7.5.698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:11:18Z","timestamp":1645485078000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.7.5.698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1975,5]]}},"alternative-id":["10.1128\/AAC.7.5.698"],"URL":"https:\/\/doi.org\/10.1128\/aac.7.5.698","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,5]]},"assertion":[{"value":"1975-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}