{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:05:42Z","timestamp":1761962742042},"reference-count":0,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[1975,6,1]],"date-time":"1975-06-01T00:00:00Z","timestamp":170812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1975,6]]},"abstract":"<jats:p>\n            The comparative efficacy of amphotericin B and amphotericin B methyl ester (AME) against experimental histoplasmosis, blastomycosis, cryptococcosis, and candidosis in mice was assessed by determining the effect of daily intraperitoneal therapy on 21-day survival and persistence of organisms in internal organs. AME, like amphotericin B, was effective against each of the experimental infections, but the efficacy was lower than the parent compound. For\n            <jats:italic>Histoplasma<\/jats:italic>\n            and\n            <jats:italic>Blastomyces<\/jats:italic>\n            infections the mean effective dose (ED\n            <jats:sub>50<\/jats:sub>\n            ) of amphotericin B was 0.3 mg\/kg, whereas the corresponding values for AME, respectively, were 2.4 and 2.8 mg\/kg. For\n            <jats:italic>Cryptococcus<\/jats:italic>\n            infection the ED\n            <jats:sub>50<\/jats:sub>\n            for amphotericin B was 0.2 mg\/kg compared with 2.0 mg\/kg for AME. The ED\n            <jats:sub>50<\/jats:sub>\n            of amphotericin B for\n            <jats:italic>Candida<\/jats:italic>\n            infection was lower than 0.05 mg\/kg and the value of AME was between 0.5 to 0.05 mg\/kg. The colony counts from internal organs of the surviving animals after the therapeutic regimens were compatible with the data on survival.\n          <\/jats:p>","DOI":"10.1128\/aac.7.6.724","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"724-729","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Comparative Chemotherapeutic Activity of Amphotericin B and Amphotericin B Methyl Ester"],"prefix":"10.1128","volume":"7","author":[{"given":"Daniel P.","family":"Bonner","sequence":"first","affiliation":[{"name":"Department of Microbiology and Waksman Institute, Rutgers University, New Brunswick, New Jersey 08903"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram P.","family":"Tewari","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Waksman Institute, Rutgers University, New Brunswick, New Jersey 08903"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Solotorovsky","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Waksman Institute, Rutgers University, New Brunswick, New Jersey 08903"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Witold","family":"Mechlinski","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Waksman Institute, Rutgers University, New Brunswick, New Jersey 08903"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl P.","family":"Schaffner","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Waksman Institute, Rutgers University, New Brunswick, New Jersey 08903"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.7.6.724","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.7.6.724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:11:35Z","timestamp":1645485095000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.7.6.724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1975,6]]}},"alternative-id":["10.1128\/AAC.7.6.724"],"URL":"https:\/\/doi.org\/10.1128\/aac.7.6.724","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,6]]},"assertion":[{"value":"1975-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}