{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T00:59:26Z","timestamp":1699664366524},"reference-count":0,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[1975,6,1]],"date-time":"1975-06-01T00:00:00Z","timestamp":170812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1975,6]]},"abstract":"<jats:p>\n            Growth of the spherule phase of\n            <jats:italic>Coccidioides immitis<\/jats:italic>\n            in liquid glucose-mineral salts medium was suppressed for 13 days by 5 to 10 \u03bcg of polymyxin B per ml. Inhibition of growth was also noted when filter paper disks containing polymyxin B were placed on the surface of arthrospore-seeded defined medium solidified with refined agar. The antibiotic evidently damaged the cytoplasmic membrane inasmuch as spherules suspended in distilled water containing 10 \u03bcg of polymyxin B per ml rapidly lost nucleotides. Leakage of nucleotides was prevented by 0.1 M Ca\n            <jats:sup>2+<\/jats:sup>\n            . The anticoccidioidal activity of amphotericin B (0.02 to 0.08 \u03bcg\/ml) was enhanced by 2.5 \u03bcg of polymyxin B per ml. Colistin (polymyxin E) methanesulfonate did not inhibit spherule growth at concentrations as high as 50 \u03bcg\/ml. This may be because colistin, though structurally similar to polymyxin B, is not cationic because its \u03b3-amino groups are masked by methanesulfonate radicals.\n          <\/jats:p>","DOI":"10.1128\/aac.7.6.781","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"781-787","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Inhibition of\n            <i>Coccidioides immitis<\/i>\n            In Vitro and Enhancement of Anticoccidioidal Effects of Amphotericin B by Polymyxin B"],"prefix":"10.1128","volume":"7","author":[{"given":"M. S.","family":"Collins","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, School of Medicine, University of California, Davis, California 95616"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Pappagianis","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Medicine, University of California, Davis, California 95616"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.7.6.781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.7.6.781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:11:05Z","timestamp":1645485065000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.7.6.781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1975,6]]}},"alternative-id":["10.1128\/AAC.7.6.781"],"URL":"https:\/\/doi.org\/10.1128\/aac.7.6.781","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,6]]},"assertion":[{"value":"1975-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}