{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:37:41Z","timestamp":1777563461527,"version":"3.51.4"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1976,5,1]],"date-time":"1976-05-01T00:00:00Z","timestamp":199756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1976,5]]},"abstract":"<jats:p>\n            The activity of cefamandole was comparable to that of cephalothin, cefazolin, and cephaloridine against\n            <jats:italic>Staphylococcus aureus, Streptococcus pyogenes<\/jats:italic>\n            , and\n            <jats:italic>Diplococcus pneumoniae<\/jats:italic>\n            . In contrast, cefamandole was considerably more active than cephalothin, cefazolin, or cephaloridine against gram-negative facultative bacilli, including\n            <jats:italic>Haemophilus influenzae<\/jats:italic>\n            , the most striking disparities being noted with indole-positive\n            <jats:italic>Proteus<\/jats:italic>\n            and\n            <jats:italic>Enterobacter. Bacteroides fragilis<\/jats:italic>\n            was more susceptible to cefoxitin than to cefamandole or cefazolin (median minimal inhibitory concentration, approximately 8, 32, and 32 \u03bcg\/ml, respectively); cephalothin exhibited still less activity against this species. The majority of other anaerobes were inhibited by relatively low concentrations of all four cephalosporins. The results indicate a potentially valuable role for cefamandole against facultative gram-negative bacilli, including\n            <jats:italic>H. influenzae<\/jats:italic>\n            , but no exceptional activity against anaerobes.\n          <\/jats:p>","DOI":"10.1128\/aac.9.5.852","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"852-855","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":46,"title":["Activity of Cefamandole and Other Cephalosporins Against Aerobic and Anaerobic Bacteria"],"prefix":"10.1128","volume":"9","author":[{"given":"E. Chaim","family":"Ernst","sequence":"first","affiliation":[{"name":"Infectious Diseases Service, New England Medical Center Hospital and Tufts University School of Medicine, Boston, Massachusetts 02111"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Berger","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, New England Medical Center Hospital and Tufts University School of Medicine, Boston, Massachusetts 02111"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Barza","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, New England Medical Center Hospital and Tufts University School of Medicine, Boston, Massachusetts 02111"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilda V.","family":"Jacobus","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, New England Medical Center Hospital and Tufts University School of Medicine, Boston, Massachusetts 02111"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis P.","family":"Tally","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, New England Medical Center Hospital and Tufts University School of Medicine, Boston, Massachusetts 02111"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.9.5.852","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.9.5.852","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:12:19Z","timestamp":1645485139000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.9.5.852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1976,5]]}},"alternative-id":["10.1128\/AAC.9.5.852"],"URL":"https:\/\/doi.org\/10.1128\/aac.9.5.852","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,5]]},"assertion":[{"value":"1976-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}