{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:01:05Z","timestamp":1791158465136,"version":"4.1.0"},"reference-count":64,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2020,5,5]]},"abstract":"<jats:p>\n            Iron is an essential element for most organisms but causes problems due to poor solubility under oxic conditions and due to toxicity by catalyzing the formation of reactive oxygen species (ROS). Therefore, bacteria have evolved complex regulatory networks for iron homeostasis aiming at a sufficient iron supply while minimizing ROS formation. In our study, the responses of the actinobacterium\n            <jats:named-content content-type=\"genus-species\">Corynebacterium glutamicum<\/jats:named-content>\n            to iron limitation were analyzed, resulting in a detailed view on the processes involved in iron homeostasis in this model organism. In particular, we provide evidence that iron limitation causes TPP deficiency, presumably due to insufficient activity of the iron-dependent phosphomethylpyrimidine synthase (ThiC). TPP deficiency was deduced from the upregulation of genes controlled by a TPP riboswitch and secretion of metabolites caused by insufficient activity of the TPP-dependent enzymes pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase. To our knowledge, the link between iron starvation and thiamine synthesis has not been elaborated previously.\n          <\/jats:p>","DOI":"10.1128\/aem.00065-20","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T09:56:30Z","timestamp":1583747790000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["The Iron Deficiency Response of Corynebacterium glutamicum and a Link to Thiamine Biosynthesis"],"prefix":"10.1128","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9105-2452","authenticated-orcid":false,"given":"Andreas","family":"K\u00fcberl","sequence":"first","affiliation":[{"name":"IBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum J\u00fclich GmbH, J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9699-3048","authenticated-orcid":false,"given":"Aliye","family":"Mengus-Kaya","sequence":"additional","affiliation":[{"name":"IBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum J\u00fclich GmbH, J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0065-3007","authenticated-orcid":false,"given":"Tino","family":"Polen","sequence":"additional","affiliation":[{"name":"IBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum J\u00fclich GmbH, J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4701-8254","authenticated-orcid":false,"given":"Michael","family":"Bott","sequence":"additional","affiliation":[{"name":"IBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum J\u00fclich GmbH, J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1490"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814412116"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-6445(03)00055-X"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1mt00022e"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12709"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2006.05.006"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1201\/9781420039696"},{"key":"e_1_3_2_9_2","volume-title":"Corynebacteria: genomics and molecular biology","author":"Frunzke J","year":"2008","unstructured":"Frunzke J, Bott M. 2008. 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