{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:54:23Z","timestamp":1790506463602,"version":"4.1.0"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"13","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"The Japan Society for the Promotion of Sciences KAKENHI","award":["JP19K19428"],"award-info":[{"award-number":["JP19K19428"]}]},{"name":"The Japan Agency for Medical Research and Development, AMED","award":["JP20fk0108120"],"award-info":[{"award-number":["JP20fk0108120"]}]},{"name":"The Japan Agency for Medical Research and Development, AMED","award":["JP19fk0108103"],"award-info":[{"award-number":["JP19fk0108103"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2020,6,17]]},"abstract":"<jats:p>\n            Antimicrobial-resistant\n            <jats:italic>Salmonella<\/jats:italic>\n            bacteria arise in farm environments through imprudent use of antimicrobials. Subsequently, these antimicrobial-resistant strains, such as extended-spectrum-\u03b2-lactamase (ESBL)-producing\n            <jats:italic>Salmonella<\/jats:italic>\n            , may be transmitted to humans via food animal-derived products. Here, we examined\n            <jats:italic>Salmonella<\/jats:italic>\n            carriage among food handlers in Japan. Overall, 164 of 145,220 fecal samples (0.113%) were positive for\n            <jats:italic>Salmonella<\/jats:italic>\n            . Among the 158 tested isolates, four were identified as ESBL-producing isolates carrying ESBL determinants\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M-15<\/jats:sub>\n            or\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M-14<\/jats:sub>\n            . In all cases, the genes coexisted with IS\n            <jats:italic>Ecp1<\/jats:italic>\n            , regardless of whether they were located on the chromosome or on a plasmid. Our findings suggest that food workers may be a reservoir of ESBL-producing strains and could contribute to the spread of resistance genes from farm-derived\n            <jats:italic>Salmonella<\/jats:italic>\n            to other bacterial species present in the human gut.\n          <\/jats:p>","DOI":"10.1128\/aem.00072-20","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T13:41:49Z","timestamp":1586785309000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Food Workers as a Reservoir of Extended-Spectrum-Cephalosporin-Resistant\n            <i>Salmonella<\/i>\n            Strains in Japan"],"prefix":"10.1128","volume":"86","author":[{"given":"Hiroaki","family":"Shigemura","sequence":"first","affiliation":[{"name":"Division of Pathology and Microbiology, Department of Health Science, Fukuoka Institute of Health and Environmental Sciences, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Sakatsume","sequence":"additional","affiliation":[{"name":"Kotobiken Medical Laboratories, Inc., Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Sekizuka","sequence":"additional","affiliation":[{"name":"Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Kotobiken Medical Laboratories, Inc., Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiko","family":"Hamada","sequence":"additional","affiliation":[{"name":"Kotobiken Medical Laboratories, Inc., Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Etoh","sequence":"additional","affiliation":[{"name":"Division of Pathology and Microbiology, Department of Health Science, Fukuoka Institute of Health and Environmental Sciences, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Carle","sequence":"additional","affiliation":[{"name":"Division of Pathology and Microbiology, Department of Health Science, Fukuoka Institute of Health and Environmental Sciences, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Mizumoto","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Shizuoka Institute of Environment and Hygiene, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Hirai","sequence":"additional","affiliation":[{"name":"Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Matsui","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Kimura","sequence":"additional","affiliation":[{"name":"School of Medical Technology, Faculty of Health Science, Gunma Paz University, Gunma, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Onozuka","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0487-4405","authenticated-orcid":false,"given":"Makoto","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Inoshima","sequence":"additional","affiliation":[{"name":"Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Murakami","sequence":"additional","affiliation":[{"name":"Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"1066","volume-title":"Feigin and Cherry\u2019s textbook of pediatric infectious diseases","author":"Ochoa JT","year":"2019","unstructured":"Ochoa JT, Santisteban-Ponce J. 2019. Salmonella (non-typhoidal), p 1066\u20131081. In Feigin RD, Cherry J, Demmler-Harrison GJ, Kaplan SL (ed), Feigin and Cherry\u2019s textbook of pediatric infectious diseases, 8th ed, vol 1. Elsevier, Philadelphia, PA.","edition":"8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ727"},{"key":"e_1_3_3_4_2","first-page":"155","article-title":"Features of Salmonella serovars among food handlers in Kyushu, Japan","volume":"30","author":"Murakami K","year":"2007","unstructured":"Murakami K, Ishihara T, Horikawa K, Oda T. 2007. Features of Salmonella serovars among food handlers in Kyushu, Japan. New Microbiol 30:155\u2013159.","journal-title":"New Microbiol"},{"key":"e_1_3_3_5_2","first-page":"137","article-title":"Occurrence and characterization of resistance to extended-spectrum cephalosporins mediated by \u03b2-lactamase CMY-2 in Salmonella isolated from food-producing animals in Canada","volume":"66","author":"Allen KJ","year":"2002","unstructured":"Allen KJ, Poppe C. 2002. Occurrence and characterization of resistance to extended-spectrum cephalosporins mediated by \u03b2-lactamase CMY-2 in Salmonella isolated from food-producing animals in Canada. Can J Vet Res 66:137\u2013144.","journal-title":"Can J Vet Res"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.11150\/kansenshogakuzasshi1970.75.815"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.JJID.2016.166"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00754-11"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02849-15"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt469"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1701.100511"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.67.54"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2201.151220"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00451-08"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00076-17"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2018.03.011"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6147.1301"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(82)93365-5"},{"key":"e_1_3_3_19_2","volume-title":"Medical microbiology","author":"Giannella AR","year":"1996","unstructured":"Giannella AR. 1996. Salmonella, chapter 21. In Baron S (ed), Medical microbiology 4th ed. The University of Texas Medical Branch at Galveston, Galveston, TX.","edition":"4"},{"key":"e_1_3_3_20_2","volume-title":"CDC Foodborne Diseases Active Surveillance Network (FoodNet): FoodNet Surveillance Report for 2012 (final report)","author":"Centers for Disease Control and Prevention","year":"2014","unstructured":"Centers for Disease Control and Prevention. 2014. CDC Foodborne Diseases Active Surveillance Network (FoodNet): FoodNet Surveillance Report for 2012 (final report). Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA."},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116927"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2017.05.003"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/35101607"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.10.2177"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000929"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evw105"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00232-07"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00575-18"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.47.9.2732-2739.2003"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx488"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.02.019"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.039487-0"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268801005283"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/463095"},{"key":"e_1_3_3_35_2","volume-title":"Performance standards for antimicrobial susceptibility testing","author":"Clinical and Laboratory Standard Institute","year":"2018","unstructured":"Clinical and Laboratory Standard Institute. 2018. 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