{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:29:45Z","timestamp":1787016585473,"version":"build-2736575974"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"14","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Science and Technology Commission of Shandong province","award":["17391902000"],"award-info":[{"award-number":["17391902000"]}]},{"name":"Ministry of Agriculture of China","award":["CARS-47-G17"],"award-info":[{"award-number":["CARS-47-G17"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772893"],"award-info":[{"award-number":["31772893"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772891"],"award-info":[{"award-number":["31772891"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["2017CXGC0103"],"award-info":[{"award-number":["2017CXGC0103"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2019,7,15]]},"abstract":"<jats:p>\n                    The alternative sigma factor RpoE is essential for the virulence of\n                    <jats:named-content content-type=\"genus-species\">Vibrio alginolyticus<\/jats:named-content>\n                    toward marine fish, coral, and other animals in response to sea surface temperature increases. In this study, we characterized another alternative sigma factor, RpoX, which is induced at high temperatures and under low-osmotic-stress conditions. The expression of\n                    <jats:italic>rpoX<\/jats:italic>\n                    is under the tight control of RpoE and RpoX. Although RpoE and RpoX coregulate 105 genes, they are programming different regulatory functions in stress responses and virulence in\n                    <jats:named-content content-type=\"genus-species\">V. alginolyticus<\/jats:named-content>\n                    . These findings illuminated the RpoE-RpoX-centered regulatory cascades and their distinct and overlapping regulatory roles in\n                    <jats:named-content content-type=\"genus-species\">V. alginolyticus<\/jats:named-content>\n                    , which facilitates unraveling of the mechanisms by which the bacterium causes diseases in various sea animals in response to temperature fluctuations as well as the development of appropriate strategies to tackle infections by this bacterium.\n                  <\/jats:p>","DOI":"10.1128\/aem.00234-19","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T06:49:47Z","timestamp":1556693387000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Alternative Sigma Factor RpoX Is a Part of the RpoE Regulon and Plays Distinct Roles in Stress Responses, Motility, Biofilm Formation, and Hemolytic Activities in the Marine Pathogen Vibrio alginolyticus"],"prefix":"10.1128","volume":"85","author":[{"given":"Dan","family":"Gu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China"},{"name":"Jiangsu Key Laboratory of Zoonosis\/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Hao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongjing","family":"Xu","sequence":"additional","affiliation":[{"name":"Yantai Tianyuan Aquatic Co. 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