{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:35:51Z","timestamp":1782509751579,"version":"3.54.5"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"14","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31602092"],"award-info":[{"award-number":["31602092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2019,7,15]]},"abstract":"<jats:p>\n            Minicircle DNA (mcDNA) has been considered an attractive alternative to DNA vaccines; however, the relatively high cost and complicated process of purifying mcDNA dramatically restricts the application of mcDNA in the veterinary field. We designed a novel\n            <jats:italic>in vivo<\/jats:italic>\n            mcDNA platform in which the complete plasmid could spontaneously transform into mcDNA\n            <jats:italic>in vivo<\/jats:italic>\n            . In combination with the regulated-delayed-lysis\n            <jats:italic>Salmonella<\/jats:italic>\n            strain, the newly designed mcDNA vaccine provides us with an elegant platform for veterinary vaccine development.\n          <\/jats:p>","DOI":"10.1128\/aem.00407-19","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T18:01:29Z","timestamp":1557165689000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["A Novel Cre Recombinase-Mediated\n            <i>In Vivo<\/i>\n            Minicircle DNA (CRIM) Vaccine Provides Partial Protection against Newcastle Disease Virus"],"prefix":"10.1128","volume":"85","author":[{"given":"Yanlong","family":"Jiang","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Jilin Provincial Engineering Research Center of Animal Probiotics, Key Lab of Animal Production, Product Quality and Security, 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