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Bdellovibrio<\/jats:named-content>\n                    has potential as a biocontrol agent, but no reports of it being tested in living animals have been published, and no data on whether\n                    <jats:named-content content-type=\"genus-species\">Bdellovibrio<\/jats:named-content>\n                    might spread between animals are available. In this study, we tried to fill this knowledge gap, using\n                    <jats:named-content content-type=\"genus-species\">B. bacteriovorus<\/jats:named-content>\n                    HD100 doses in poultry with a normal gut microbiota or predosed with a colonizing\n                    <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n                    strain. In both cases,\n                    <jats:named-content content-type=\"genus-species\">Bdellovibrio<\/jats:named-content>\n                    was dosed orally along with antacids. After dosing non-\n                    <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n                    -infected birds with\n                    <jats:named-content content-type=\"genus-species\">Bdellovibrio<\/jats:named-content>\n                    , we measured the health and well-being of the birds and any changes in their gut pathology and culturable microbiota, finding that although a\n                    <jats:named-content content-type=\"genus-species\">Bdellovibrio<\/jats:named-content>\n                    dose at 2 days of age altered the overall diversity of the natural gut microbiota in 28-day-old birds, there were no adverse effects on their growth and well-being. Drinking water and fecal matter from the pens in which the birds were housed as groups showed no contamination by\n                    <jats:named-content content-type=\"genus-species\">Bdellovibrio<\/jats:named-content>\n                    after dosing. Predatory\n                    <jats:named-content content-type=\"genus-species\">Bdellovibrio<\/jats:named-content>\n                    orally administered to birds that had been predosed with a gut-colonizing\n                    <jats:named-content content-type=\"genus-species\">Salmonella enterica<\/jats:named-content>\n                    serovar Enteritidis phage type 4 strain (an important zoonotic pathogen) significantly reduced\n                    <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n                    numbers in bird gut cecal contents and reduced abnormal cecal morphology, indicating reduced cecal inflammation, compared to the ceca of the untreated controls or a nonpredatory \u0394\n                    <jats:italic>pilA<\/jats:italic>\n                    strain, suggesting that these effects were due to predatory action. This work is a first step to applying\n                    <jats:named-content content-type=\"genus-species\">Bdellovibrio<\/jats:named-content>\n                    therapeutically for other animal, and possibly human, infections.\n                  <\/jats:p>","DOI":"10.1128\/aem.00426-11","type":"journal-article","created":{"date-parts":[[2011,6,25]],"date-time":"2011-06-25T19:16:27Z","timestamp":1309029387000},"page":"5794-5803","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":163,"title":["Effects of Orally Administered Bdellovibrio bacteriovorus on the Well-Being and Salmonella Colonization of Young Chicks"],"prefix":"10.1128","volume":"77","author":[{"given":"Robert J.","family":"Atterbury","sequence":"first","affiliation":[{"name":"Centre for Genetics and Genomics, School of Biology, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom"},{"name":"School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Leicestershire LE12 5RD, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Hobley","sequence":"additional","affiliation":[{"name":"Centre for Genetics and Genomics, School of Biology, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Till","sequence":"additional","affiliation":[{"name":"Centre for Genetics and Genomics, School of Biology, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carey","family":"Lambert","sequence":"additional","affiliation":[{"name":"Centre for Genetics and Genomics, School of Biology, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Capeness","sequence":"additional","affiliation":[{"name":"Centre for Genetics and Genomics, School of Biology, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Lerner","sequence":"additional","affiliation":[{"name":"Centre for Genetics and Genomics, School of Biology, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K.","family":"Fenton","sequence":"additional","affiliation":[{"name":"Centre for Genetics and Genomics, School of Biology, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Barrow","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Leicestershire LE12 5RD, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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