{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:24:27Z","timestamp":1791462267997,"version":"4.3.4"},"reference-count":60,"publisher":"American Society for Microbiology","issue":"13","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2018YEE0105600"],"award-info":[{"award-number":["2018YEE0105600"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31570048"],"award-info":[{"award-number":["31570048"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2020,6,17]]},"abstract":"<jats:p>\n            This study analyzed the impact of\n            <jats:italic>isiA<\/jats:italic>\n            deletion on the transcriptomic profile of\n            <jats:italic>Synechocystis<\/jats:italic>\n            . The\n            <jats:italic>isiA<\/jats:italic>\n            gene encodes an iron stress-induced chlorophyll-binding protein, which is significantly induced under iron starvation. The deletion of\n            <jats:italic>isiA<\/jats:italic>\n            affects the expression of various genes that are involved in photosynthesis and ABC transporters. WGCNA revealed three functional modules in which the blue module was correlated with oxidative stress. We further demonstrated that the\n            <jats:italic>isi<\/jats:italic>\n            operon contained the following five genes:\n            <jats:italic>isiA<\/jats:italic>\n            ,\n            <jats:italic>isiB<\/jats:italic>\n            ,\n            <jats:italic>isiC<\/jats:italic>\n            ,\n            <jats:italic>ssl0461<\/jats:italic>\n            , and\n            <jats:italic>dfp<\/jats:italic>\n            by cotranscriptional PCR. Three sRNAs were identified that were related to oxidative stress. This study enhances our knowledge of IsiA-regulatory mechanisms under iron deficiency and oxidative stress.\n          <\/jats:p>","DOI":"10.1128\/aem.00517-20","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T14:06:41Z","timestamp":1587737201000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Transcriptome Analysis Reveals IsiA-Regulatory Mechanisms Underlying Iron Depletion and Oxidative-Stress Acclimation in\n            <i>Synechocystis<\/i>\n            sp. Strain PCC 6803"],"prefix":"10.1128","volume":"86","author":[{"given":"Yarui","family":"Cheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3mb70188c"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.27883-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/2.4.153"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/3.3.109"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-marine-121211-172356"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.111.3.661"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.7.2715"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297914030067"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1559"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2008.00134.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2013.11.011"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2240"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(93)90134-2"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.arplant.50.1.333"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201300522"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(90)90213-N"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0300-483x(00)00306-1"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2011.08.005"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11120-007-9151-7"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.04.010"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.104.042770"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00800"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.170.11.5018-5026.1988"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1977.tb00612.x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.109.141853"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-5561-1_8"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-4730-x"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.74.1.90"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1998.tb13336.x"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-003-0618-4"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3054.2006.00781.x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2016.10.009"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/35089104"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/35089098"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018753"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.03.021"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1099\/13500872-142-6-1469"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600927103"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-004-4340-5"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1518"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2006.02959.x"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601512"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11120-016-0257-7"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.arplant.57.032905.105350"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.105.040121"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-091014-104322"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060224"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-13-613"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00703.x"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-0227-8_25"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1998.tb12916.x"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-111-1-1"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00457-19"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00323-07"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034983"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-559"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1555-8"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1754"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-8-r90"}],"container-title":["Applied and Environmental Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AEM.00517-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AEM.00517-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T19:06:25Z","timestamp":1645643185000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AEM.00517-20"}},"subtitle":[],"editor":[{"given":"Robert M.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,17]]},"references-count":60,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2020,6,17]]}},"alternative-id":["10.1128\/AEM.00517-20"],"URL":"https:\/\/doi.org\/10.1128\/aem.00517-20","relation":{},"ISSN":["0099-2240","1098-5336"],"issn-type":[{"value":"0099-2240","type":"print"},{"value":"1098-5336","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,17]]},"assertion":[{"value":"2020-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00517-20"}}