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Here, we report genomic characterization of a multidrug-resistant\n                      <jats:italic toggle=\"yes\">V. sinaloensis<\/jats:italic>\n                      strain, ZZ006, isolated from diseased shrimp and evaluate phage-mediated suppression of this strain\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      . The ZZ006 genome harbors multiple putative virulence-associated secretion systems and antimicrobial resistance genes, suggesting chromosomal carriage of traits potentially relevant to host association and antimicrobial tolerance. Using this isolate and its phage-resistant derivatives as hosts, we isolated and characterized three novel bacteriophages (VS1, VS2, VS3) with complementary infection strategies. Their combined application efficiently suppressed ZZ006 growth\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      and reduced the emergence of phage-resistant populations compared with individual phages. Whole-genome resequencing of cocktail-resistant isolates revealed recurrent mutations in pilus- and pseudopilin-associated genes, consistent with receptor-level phage resistance. This study provides genomic characterization of an aquaculture-associated\n                      <jats:italic toggle=\"yes\">V. sinaloensis<\/jats:italic>\n                      isolate and establishes an\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      framework for phage cocktail suppression and resistance-evolution analysis, supporting future evaluation of phage-based biocontrol in aquaculture-relevant settings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>IMPORTANCE<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Vibrio sinaloensis<\/jats:italic>\n                      has been detected in diseased aquaculture animals, and multidrug-resistant isolates may complicate disease management. By integrating genomic analysis with experimental phage therapy, this work characterizes a multidrug-resistant\n                      <jats:italic toggle=\"yes\">V. sinaloensis<\/jats:italic>\n                      isolate from diseased shrimp and evaluates\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      phage-mediated suppression of this isolate and its phage-resistance evolution. These findings offer actionable solutions for mitigating antibiotic resistance and enhancing sustainability in aquaculture systems.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aem.00680-26","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:29:12Z","timestamp":1787232552000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Genomic characterization and phage cocktail suppression of a multidrug-resistant\n                    <i>Vibrio sinaloensis<\/i>\n                    isolate from diseased shrimp"],"prefix":"10.1128","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1960-6597","authenticated-orcid":false,"given":"Zhongfeixue","family":"Wang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04rdtx186","id-type":"ROR","asserted-by":"publisher"}],"name":"College of Marine Life Sciences, Institute of 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