{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:12:38Z","timestamp":1788873158770,"version":"build-2803163510"},"reference-count":127,"publisher":"American Society for Microbiology","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["CRC-2020-00257"],"award-info":[{"award-number":["CRC-2020-00257"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Alkaline soda lakes are high-pH environments that host specialized microbial communities with potential for biotechnology and natural product discovery. We characterized three\n                      <jats:italic toggle=\"yes\">Sodalinema<\/jats:italic>\n                      -dominated cyanobacterial consortia enriched from Canadian soda lakes over 510 days. Using hybrid metagenomic sequencing and metatranscriptomics across pH, alkalinity, and temperature gradients, we reconstructed high-quality metagenome-assembled genomes and assessed functional activity. All consortia converged toward cyanobacteria dominance and exhibited temperature optima between 21\u00b0C and 30\u00b0C. Phylogenetic analysis placed\n                      <jats:italic toggle=\"yes\">Sodalinema<\/jats:italic>\n                      genomes within a distinct clade affiliated with\n                      <jats:italic toggle=\"yes\">Candidatus<\/jats:italic>\n                      Sodalinema alkaliphilum. Genomic analysis indicated complete biosynthetic pathways for vitamin B5, vitamin B7, and the molybdenum cofactor, but incomplete pathways for vitamins B1, B9, and B12, consistent with patterns observed in\n                      <jats:italic toggle=\"yes\">Sodalinema yuhuli<\/jats:italic>\n                      . Metatranscriptomic profiles showed increased expression of genes involved in phycocyanin and carotenoid biosynthesis at pH 10.2 relative to pH 8.5. Biosynthetic gene cluster analysis revealed that most secondary metabolic potential resided in heterotrophic community members.\n                      <jats:italic toggle=\"yes\">Roseinatronobacter<\/jats:italic>\n                      encoded pathways for N-acyl homoserine lactones, osmoprotectants, betalactones, and prodigiosin, while\n                      <jats:italic toggle=\"yes\">Alkalimonas<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Wenzhouxiangella<\/jats:italic>\n                      , and members of the\n                      <jats:italic toggle=\"yes\">Kiloniellales<\/jats:italic>\n                      encoded clusters for lanthipeptides, cyclodipeptides, hydrogen cyanide, and pyrroloquinoline quinone. These findings indicate functional partitioning within the consortia and highlight the contribution of heterotrophs to secondary metabolism.\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        Alkaline soda lakes contain microbial communities adapted to high pH that remain underexplored for biotechnology. This study focuses on\n                        <jats:italic toggle=\"yes\">Sodalinema<\/jats:italic>\n                        , a filamentous cyanobacterium that dominates enriched consortia from Canadian soda lakes, and its associated heterotrophic partners. We show that while\n                        <jats:italic toggle=\"yes\">Sodalinema<\/jats:italic>\n                        drives primary productivity, heterotrophic bacteria encode most of the pathways for antimicrobial and signaling compounds. These interactions may support community stability and defense against competing microorganisms. By linking genomic potential with gene expression, this work identifies alkaline cyanobacterial consortia as a source of bioactive compounds and provides a framework for exploring extremophilic microbial communities for natural product discovery.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/aem.00780-26","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:00:27Z","timestamp":1788872427000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Genome mining of alkaliphilic cyanobacterial consortia: identification of biosynthetic gene clusters in\n                    <i>Sodalinema<\/i>\n                    and associated heterotrophs"],"prefix":"10.1128","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0732-7785","authenticated-orcid":true,"given":"Ruchita","family":"Solanki","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yjb2x39","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Earth, Energy, and Environment, University of Calgary","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Everet","family":"Wiszniak","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yjb2x39","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biological Sciences, University of Calgary","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6921-1984","authenticated-orcid":true,"given":"Lianchun","family":"Yi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yjb2x39","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Earth, Energy, and Environment, University of Calgary","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamaliel","family":"Cabria","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yjb2x39","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Earth, Energy, and Environment, University of Calgary","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9600-3828","authenticated-orcid":true,"given":"Marc","family":"Strous","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yjb2x39","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Earth, Energy, and Environment, University of Calgary","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7636-2778","authenticated-orcid":false,"given":"Francisco Daniel","family":"Davila Aleman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yjb2x39","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biological Sciences, University of Calgary","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.5038\/1827-806X.51.3.2422"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1113707"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.2138\/gselements.19.1.30"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ympev.2022.107454"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2017.04.002"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2020.102069"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2018.07.011"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.btre.2018.e00280"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2023.102995"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/ind.2015.0006"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biombioe.2012.12.019"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/bit.26974"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2017.11.002"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.algal.2021.102249"},{"key":"e_1_3_4_16_2","first-page":"1","volume-title":"Algae biomass: production and use","author":"Oswald WJ","year":"1980","unstructured":"Oswald WJ. 1980. 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