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Chemical control of these pathogens is complicated, because their life cycle combines intracellular vascular stages in plant hosts with transmission by highly mobile insect vectors. To date, \u201c\n            <jats:italic>Candidatus<\/jats:italic>\n            Liberibacter\u201d species are mostly unculturable, except for\n            <jats:named-content content-type=\"genus-species\">Liberibacter crescens<\/jats:named-content>\n            , a member of the genus that has been used as a model for\n            <jats:italic>in vitro<\/jats:italic>\n            assays. Here, we evaluated the potential of Zinkicide (ZnK) as an antimicrobial against \u201c\n            <jats:italic>Candidatus<\/jats:italic>\n            Liberibacter\u201d species in batch cultures and under flow conditions, using\n            <jats:named-content content-type=\"genus-species\">L. crescens<\/jats:named-content>\n            as a biological model. ZnK displayed bactericidal activity against\n            <jats:named-content content-type=\"genus-species\">L. crescens<\/jats:named-content>\n            in batch cultures and showed increased mobility and bactericidal activity in microfluidic devices resembling \u201c\n            <jats:italic>Candidatus<\/jats:italic>\n            Liberibacter\u201d species natural habitats. ZnK performance observed here against\n            <jats:named-content content-type=\"genus-species\">L. crescens<\/jats:named-content>\n            makes this compound a promising candidate to control plant diseases caused by vascular pathogens.\n          <\/jats:p>","DOI":"10.1128\/aem.00788-20","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T13:15:53Z","timestamp":1592399753000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Zinkicide Is a ZnO-Based Nanoformulation with Bactericidal Activity against Liberibacter crescens in Batch Cultures and in Microfluidic Chambers Simulating Plant Vascular Systems"],"prefix":"10.1128","volume":"86","author":[{"given":"Eber","family":"Naranjo","sequence":"first","affiliation":[{"name":"Department of Entomology and Plant Pathology, Auburn University, Auburn, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus V.","family":"Merfa","sequence":"additional","affiliation":[{"name":"Department of Entomology and Plant Pathology, Auburn University, Auburn, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swadeshmukul","family":"Santra","sequence":"additional","affiliation":[{"name":"NanoScience Technology Center, University of Central Florida, Orlando, Florida, USA"},{"name":"Department of Chemistry, University of Central Florida, Orlando, Florida, USA"},{"name":"Department of Materials Science and Engineering, University of Central Florida, Orlando, Florida, USA"},{"name":"Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ozcan","sequence":"additional","affiliation":[{"name":"NanoScience Technology Center, University of Central Florida, Orlando, Florida, USA"},{"name":"Department of Chemistry, University of Central Florida, Orlando, Florida, USA"},{"name":"Vocational School of Technical Sciences, Karamanoglu Mehmetbey University, Karaman, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Johnson","sequence":"additional","affiliation":[{"name":"Citrus Research and Education Center, University of Florida, Lake Alfred, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Cobine","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Auburn University, Auburn, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0027-4840","authenticated-orcid":false,"given":"Leonardo","family":"De La Fuente","sequence":"additional","affiliation":[{"name":"Department of Entomology and Plant Pathology, Auburn University, Auburn, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"A Review of the citrus greening research and development efforts supported by the Citrus Research and Development Foundation","author":"National Academies of Sciences, Engineering, and Medicine","year":"2018","unstructured":"National Academies of Sciences, Engineering, and Medicine. 2018. 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