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Such flexibility generates a selective advantage under fluctuating environmental conditions. It can also explain the different observations reported in PAO literature, including the capacity of \u201c\n            <jats:italic>Ca<\/jats:italic>\n            . Accumulibacter phosphatis\u201d to act like glycogen-accumulating organisms (GAOs). These observations stem from slightly different experimental conditions, and controversy arises only when one assumes that metabolism can operate only in a single mode. Furthermore, we also show how the study of metabolic strategies is possible when combining omics data with functional cofactor assays and modeling. Genomic information can only provide the potential of a microorganism. The environmental context and other complementary approaches are still needed to study and predict the functional expression of such metabolic potential.\n          <\/jats:p>","DOI":"10.1128\/aem.00808-20","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T09:42:41Z","timestamp":1601977361000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Revealing the Metabolic Flexibility of \u201c\n            <i>Candidatus<\/i>\n            Accumulibacter phosphatis\u201d through Redox Cofactor Analysis and Metabolic Network Modeling"],"prefix":"10.1128","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6617-771X","authenticated-orcid":false,"given":"Leonor","family":"Guedes da Silva","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Delft University of Technology, Delft, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0435-7640","authenticated-orcid":false,"given":"Karel","family":"Olavarria Gamez","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Delft University of Technology, Delft, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana","family":"Castro Gomes","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Delft University of Technology, Delft, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasper","family":"Akkermans","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Delft University of Technology, Delft, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurens","family":"Welles","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Delft University of Technology, Delft, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Delft University of Technology, Delft, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0658-4775","authenticated-orcid":false,"given":"Mark C. 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