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The habituation of possums to food and shelter available in human settlements has facilitated interaction with people, pets, and zoo animals, increasing the potential for transmission of zoonotic\n            <jats:italic>Cryptosporidium<\/jats:italic>\n            pathogens. This study sought to examine the identity and prevalence of\n            <jats:italic>Cryptosporidium<\/jats:italic>\n            species occurring in possums adapted to urban settings compared to possums inhabiting remote woodlands far from urban areas and to characterize the health of the host in response to oocyst shedding. Findings indicated that both populations were shedding oocysts of the same genotype (brushtail possum 1 [BTP1]) that were genetically and morphologically distinct from zoonotic species and genotypes and most closely related to\n            <jats:italic>Cryptosporidium<\/jats:italic>\n            species from marsupials. The urban population was shedding an additional five\n            <jats:italic>Cryptosporidium<\/jats:italic>\n            isolates that were genetically distinct from BTP1 and formed a sister clade with\n            <jats:italic>Cryptosporidium parvum<\/jats:italic>\n            and\n            <jats:italic>Cryptosporidium hominis<\/jats:italic>\n            . Possums that were shedding oocysts showed no evidence of pathogenic changes, including elevated levels of white blood cells, diminished body condition (body mass divided by skeletal body length), or reduced nutritional state, suggesting a stable host-parasite relationship typical of\n            <jats:italic>Cryptosporidium<\/jats:italic>\n            species that are adapted to the host. Overall,\n            <jats:italic>Cryptosporidium<\/jats:italic>\n            occurred with a higher prevalence in possums from urban habitat (11.3%) than in possums from woodland habitat (5.6%); however, the host-specific nature of the genotypes may limit spillover infection in the urban setting. This study determined that the coexistence of possums with sympatric populations of humans, pets, and zoo animals in the urban Australian environment is unlikely to present a threat to public health safety.\n          <\/jats:p>","DOI":"10.1128\/aem.00809-08","type":"journal-article","created":{"date-parts":[[2008,7,19]],"date-time":"2008-07-19T01:06:21Z","timestamp":1216429581000},"page":"5549-5555","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["Prevalence and Genetic Characterization of\n            <i>Cryptosporidium<\/i>\n            Isolates from Common Brushtail Possums (\n            <i>Trichosurus vulpecula<\/i>\n            ) Adapted to Urban Settings"],"prefix":"10.1128","volume":"74","author":[{"given":"Nichola J.","family":"Hill","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Macquarie University, North Ryde, New South Wales 2109, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M.","family":"Deane","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Macquarie University, North Ryde, New South Wales 2109, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle L.","family":"Power","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Macquarie University, North Ryde, New South Wales 2109, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.67.6.2840-2843.2001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.11.6748-6752.2004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.63.10.3946-3949.1997"},{"key":"e_1_3_2_6_2","first-page":"192","volume":"42","year":"1997","unstructured":"Bajer, A., M. 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