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All complete cp32s contain an\n            <jats:italic>erp<\/jats:italic>\n            locus, which encodes surface-exposed proteins. Sequences were compared for all 193\n            <jats:italic>erp<\/jats:italic>\n            alleles carried by 22 different strains of Lyme disease-causing spirochete to investigate their natural diversity and evolutionary histories. These included multiple isolates from a focus where Lyme disease is endemic in the northeastern United States and isolates from across North America and Europe. Bacteria were derived from diseased humans and from vector ticks and included members of 5 different\n            <jats:named-content content-type=\"genus-species\">Borrelia<\/jats:named-content>\n            genospecies. All\n            <jats:italic>erp<\/jats:italic>\n            operon 5\u2032-noncoding regions were found to be highly conserved, as were the initial 70 to 80 bp of all\n            <jats:italic>erp<\/jats:italic>\n            open reading frames, traits indicative of a common evolutionary origin. However, the majority of the protein-coding regions are highly diverse, due to numerous intra- and intergenic recombination events. Most\n            <jats:italic>erp<\/jats:italic>\n            alleles are chimeras derived from sequences of closely related and distantly related\n            <jats:italic>erp<\/jats:italic>\n            sequences and from unknown origins. Since known functions of Erp surface proteins involve interactions with various host tissue components, this diversity may reflect both their multiple functions and the abilities of Lyme disease-causing spirochetes to successfully infect a wide variety of vertebrate host species.\n          <\/jats:p>","DOI":"10.1128\/aem.00817-13","type":"journal-article","created":{"date-parts":[[2013,4,27]],"date-time":"2013-04-27T01:27:43Z","timestamp":1367026063000},"page":"4115-4128","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Distribution of cp32 Prophages among Lyme Disease-Causing Spirochetes and Natural Diversity of Their Lipoprotein-Encoding\n            <i>erp<\/i>\n            Loci"],"prefix":"10.1128","volume":"79","author":[{"given":"Dustin","family":"Brisson","sequence":"first","affiliation":[{"name":"Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon L.","family":"Jutras","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherwood","family":"Casjens","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Microbiology and Immunology, University of Utah Medical School, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/37551"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.1.217-227.1997"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01698.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.21.6254-6258.2000"},{"key":"e_1_3_3_6_2","first-page":"27","volume-title":"Borrelia: molecular biology, host interaction and pathogenesis","author":"Casjens SR","year":"2010","unstructured":"CasjensSR EggersCH SchwartzI. 2010. 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