{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:10:41Z","timestamp":1790104241747,"version":"4.0.1"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"18","license":[{"start":{"date-parts":[[2013,9,15]],"date-time":"2013-09-15T00:00:00Z","timestamp":1379203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2013,9,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of cereal gluten proteins. This disorder is associated with imbalances in the gut microbiota composition that could be involved in the pathogenesis of CD. The aim of this study was to characterize the composition and diversity of the cultivable duodenal mucosa-associated bacteria of CD patients and control children. Duodenal biopsy specimens from patients with active disease on a gluten-containing diet (<jats:italic>n<\/jats:italic>= 32), patients with nonactive disease after adherence to a gluten-free diet (<jats:italic>n<\/jats:italic>= 17), and controls (<jats:italic>n<\/jats:italic>= 8) were homogenized and plated on plate count agar, Wilkins-Chalgren agar, brain heart agar, or yeast, Casitone, and fatty acid agar. The isolates were identified by partial 16S rRNA gene sequencing. Renyi diversity profiles showed the highest diversity values for active CD patients, followed by nonactive CD patients and control individuals. Members of the phylum<jats:named-content content-type=\"genus-species\">Proteobacteria<\/jats:named-content>were more abundant in patients with active CD than in the other child groups, while those of the phylum<jats:named-content content-type=\"genus-species\">Firmicutes<\/jats:named-content>were less abundant. Members of the families<jats:named-content content-type=\"genus-species\">Enterobacteriaceae<\/jats:named-content>and<jats:named-content content-type=\"genus-species\">Staphylococcaceae<\/jats:named-content>, particularly the species<jats:named-content content-type=\"genus-species\">Klebsiella oxytoca<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">Staphylococcus epidermidis<\/jats:named-content>, and<jats:named-content content-type=\"genus-species\">Staphylococcus pasteuri<\/jats:named-content>, were more abundant in patients with active disease than in controls. In contrast, members of the family<jats:named-content content-type=\"genus-species\">Streptococcaceae<\/jats:named-content>were less abundant in patients with active CD than in controls. Furthermore, isolates of the<jats:named-content content-type=\"genus-species\">Streptococcus anginosus<\/jats:named-content>and<jats:named-content content-type=\"genus-species\">Streptococcus mutans<\/jats:named-content>groups were more abundant in controls than in both CD patient groups, regardless of inflammatory status. The findings indicated that the disease is associated with the overgrowth of possible pathobionts that exclude symbionts or commensals that are characteristic of the healthy small intestinal microbiota.<\/jats:p>","DOI":"10.1128\/aem.00869-13","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T01:55:33Z","timestamp":1373334933000},"page":"5472-5479","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":147,"title":["Duodenal-Mucosal Bacteria Associated with Celiac Disease in Children"],"prefix":"10.1128","volume":"79","author":[{"given":"Ester","family":"S\u00e1nchez","sequence":"first","affiliation":[{"name":"Microbial Ecology and Nutrition Research Group, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Donat","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Ribes-Koninckx","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Leonor","family":"Fern\u00e1ndez-Murga","sequence":"additional","affiliation":[{"name":"Microbial Ecology and Nutrition Research Group, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Sanz","sequence":"additional","affiliation":[{"name":"Microbial Ecology and Nutrition Research Group, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.035345"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70134-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.465"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901919"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2005.02.017"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2005.02.003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1094\/CCHEM-85-1-0001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389557510909030359"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.543"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2008.01.011"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00741.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.151571"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-11-219"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-8-50"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2010.076950"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2012-200759"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2007.00337.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-10-175"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.061366"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47410-0"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016169"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0709471"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/jcb.22459","article-title":"Bifidobacteria inhibit the inflammatory response induced by gliadins in intestinal epithelial cells via modifications of toxic peptide generation during digestion","volume":"109","author":"Laparra JM","year":"2010","unstructured":"LaparraJMSanzY. 2010. 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