{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T08:26:34Z","timestamp":1775809594977,"version":"3.50.1"},"reference-count":60,"publisher":"American Society for Microbiology","issue":"19","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The three closely related species that currently comprise the genus\n            <jats:named-content content-type=\"genus-species\">Salinispora<\/jats:named-content>\n            were analyzed using a multilocus sequence typing approach targeting 48 strains derived from four geographic locations. Phylogenetic congruence and a well-supported concatenated tree provide strong support for the delineation of the three species as currently described and the basal relationship of\n            <jats:named-content content-type=\"genus-species\">Salinispora arenicola<\/jats:named-content>\n            to the more recently diverged sister taxa\n            <jats:named-content content-type=\"genus-species\">S. tropica<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">S. pacifica<\/jats:named-content>\n            . The phylogeny of the initial region of the\n            <jats:italic>rpoB<\/jats:italic>\n            gene sequenced was atypical, placing the related genera\n            <jats:named-content content-type=\"genus-species\">Micromonospora<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Verrucosispora<\/jats:named-content>\n            within the\n            <jats:named-content content-type=\"genus-species\">Salinispora<\/jats:named-content>\n            clade. This phylogenetic incongruence was subsequently ascribed to a homologous-recombination event in a portion of the gene associated with resistance to compounds in the rifamycin class, which target RpoB. All\n            <jats:named-content content-type=\"genus-species\">S. arenicola<\/jats:named-content>\n            strains produced compounds in this class and possessed resistance-conferring amino acid changes in RpoB. The phylogeny of a region of the\n            <jats:italic>rpoB<\/jats:italic>\n            gene that is not associated with rifamycin resistance was congruent with the other housekeeping genes. The link between antibiotic resistance and homologous recombination suggests that incongruent phylogenies provide opportunities to identify the molecular targets of secondary metabolites, an observation with potential relevance for drug discovery efforts. Low ratios of interspecies recombination to mutation, even among cooccurring strains, coupled with high levels of within-species recombination suggest that the three species have been described in accordance with natural barriers to recombination.\n          <\/jats:p>","DOI":"10.1128\/aem.00880-13","type":"journal-article","created":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T07:27:30Z","timestamp":1374910050000},"page":"5997-6005","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Multilocus Sequence Typing Reveals Evidence of Homologous Recombination Linked to Antibiotic Resistance in the Genus Salinispora"],"prefix":"10.1128","volume":"79","author":[{"given":"Kelle C.","family":"Freel","sequence":"first","affiliation":[{"name":"Scripps Institution of Oceanography, Center for Marine Biotechnology and Biomedicine, University of California\u2014San Diego, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Mill\u00e1n-Agui\u00f1aga","sequence":"additional","affiliation":[{"name":"Scripps Institution of Oceanography, Center for Marine Biotechnology and Biomedicine, University of California\u2014San Diego, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul R.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Scripps Institution of Oceanography, Center for Marine Biotechnology and Biomedicine, University of California\u2014San Diego, La Jolla, California, 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