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The aquatic environment is the natural reservoir for\n                    <jats:named-content content-type=\"genus-species\">V. cholerae<\/jats:named-content>\n                    , where it can survive alterations in temperature, salinity, and oxygen. The second messenger molecule c-di-GMP is an important signal regulating host and aquatic environmental persistence because it controls whether\n                    <jats:named-content content-type=\"genus-species\">V. cholerae<\/jats:named-content>\n                    will form a biofilm or disperse through flagellar motility. In this work, we demonstrate another function of c-di-GMP in\n                    <jats:named-content content-type=\"genus-species\">V. cholerae<\/jats:named-content>\n                    biology: promoting tolerance to the reactive oxygen species H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    through the differential regulation of catalase expression. Our results suggest a mechanism where c-di-GMP simultaneously controls biofilm formation and antioxidant production, which could promote persistence in human and marine environments.\n                  <\/jats:p>","DOI":"10.1128\/aem.01043-19","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T08:36:03Z","timestamp":1562834163000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Cyclic di-GMP Increases Catalase Production and Hydrogen Peroxide Tolerance in\n                    <i>Vibrio cholerae<\/i>"],"prefix":"10.1128","volume":"85","author":[{"given":"Nicolas L.","family":"Fernandez","sequence":"first","affiliation":[{"name":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Waters","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00375"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/es00175a004"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195981"},{"key":"e_1_3_3_5_2","first-page":"655","article-title":"Production of extracellular reactive oxygen species by phytoplankton: past and future directions","volume":"40","author":"Diaz JM","year":"2018","unstructured":"Diaz JM, Plummer S. 2018. 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