{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:42:49Z","timestamp":1790826169111,"version":"4.1.0"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"18","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["1008863"],"award-info":[{"award-number":["1008863"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>\n            Third-generation cephalosporins, such as ceftiofur, are commonly used to treat metritis in dairy cows. Chitosan microparticles has been shown to have a broad spectrum of activity\n            <jats:italic>in vitro<\/jats:italic>\n            and to be effective against uterine pathogens\n            <jats:italic>in vivo<\/jats:italic>\n            ; therefore, they have been hailed as a possible alternative to traditional antibiotics. Nonetheless, in the present study, we saw that chitosan microparticle treatment slowed the progression of the uterine microbiome of cows with metritis toward a healthy state, whereas ceftiofur treatment hastened the progression toward a healthy state. Given the lack of an effective alternative to traditional antibiotics and an increased concern about antimicrobial resistance, a greater effort should be devoted to the prevention of metritis in dairy cows.\n          <\/jats:p>","DOI":"10.1128\/aem.01066-20","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T13:46:22Z","timestamp":1594388782000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Effect of Chitosan Microparticles on the Uterine Microbiome of Dairy Cows with Metritis"],"prefix":"10.1128","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6683-4476","authenticated-orcid":false,"given":"Klibs N.","family":"Galv\u00e3o","sequence":"first","affiliation":[{"name":"Department of Large Animal Clinical Sciences, University of Florida, Gainesville, Florida, USA"},{"name":"D. H. 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