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Anoxygenic phototrophs are one of the few drivers of Fe(II) oxidation in anoxic environments and are thought to contribute significantly to iron cycling in both modern and ancient environments. These organisms thrive at high Fe(II) concentrations, yet the adaptations required to tolerate the stresses associated with this are unclear. Despite the general consensus that high Fe(II) concentrations pose numerous stresses on these organisms, our study of the large-scale proteome response of a model anoxygenic phototroph to Fe(II) oxidation demonstrates that common iron homeostasis strategies are adequate to manage this. The bulk of the proteome response is not driven by adaptations to Fe(II) stress but to adaptations required to utilize an inorganic carbon source. Such a global overview of the adaptation of these organisms to Fe(II) oxidation provides valuable insights into the physiology of these biogeochemically important organisms and suggests that Fe(II) oxidation may not pose as many challenges to anoxygenic phototrophs as previously thought.<\/jats:p>","DOI":"10.1128\/aem.01166-18","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T09:58:44Z","timestamp":1528797524000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Proteome Response of a Metabolically Flexible Anoxygenic Phototroph to Fe(II) Oxidation"],"prefix":"10.1128","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1132-5201","authenticated-orcid":false,"given":"Casey","family":"Bryce","sequence":"first","affiliation":[{"name":"Geomicrobiology, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirita","family":"Franz-Wachtel","sequence":"additional","affiliation":[{"name":"Proteome Center T\u00fcbingen, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas C.","family":"Nalpas","sequence":"additional","affiliation":[{"name":"Proteome Center T\u00fcbingen, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennyfer","family":"Miot","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, MNHN, UMR 7590 CNRS, Institut de Min\u00e9ralogie, Physique des Mat\u00e9riaux et de Cosmochimie, IMPMC, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0553-0137","authenticated-orcid":false,"given":"Karim","family":"Benzerara","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, MNHN, UMR 7590 CNRS, Institut de Min\u00e9ralogie, Physique des Mat\u00e9riaux et de Cosmochimie, IMPMC, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4399-7336","authenticated-orcid":false,"given":"James M.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Geomicrobiology, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8304-9149","authenticated-orcid":false,"given":"Sara","family":"Kleindienst","sequence":"additional","affiliation":[{"name":"Geomicrobiology, University of T\u00fcbingen, T\u00fcbingen, Germany"},{"name":"Microbial Ecology, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1206-2458","authenticated-orcid":false,"given":"Boris","family":"Macek","sequence":"additional","affiliation":[{"name":"Proteome Center T\u00fcbingen, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3558-9500","authenticated-orcid":false,"given":"Andreas","family":"Kappler","sequence":"additional","affiliation":[{"name":"Geomicrobiology, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1130\/0091-7613(2002)030<1079:CBHFTP>2.0.CO;2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/sed.12051"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1130\/G21658.1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep13803"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805313105"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.01584-16"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00713"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.13587"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.8.4487-4496.2005"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.60.12.4517-4526.1994"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03527-15"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsec\/fix054"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6941.12315"},{"key":"e_1_3_3_15_2","first-page":"729","article-title":"Rhodovulum iodosum sp. nov. and Rhodovulum robiginosum sp. nov., two new marine phototrophic ferrous-iron-oxidizing purple bacteria","volume":"49","author":"Straub KL","year":"1999","unstructured":"Straub KL, Raineyr FA, Widdell F. 1999. 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