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In this study, we report a unidirectional alteration in antibiotic resistance from susceptibility to increased resistance. Highly sensitive\n            <jats:named-content content-type=\"genus-species\">Salmonella enterica<\/jats:named-content>\n            serovar Typhimurium isolates from organic farm systems quickly acquired tetracycline resistance under antibiotic pressure in simulated farm soil environments within 2 weeks, with expression of antibiotic resistance-related genes that was significantly upregulated. Conversely, originally resistant\n            <jats:italic>S<\/jats:italic>\n            . Typhimurium isolates from conventional farm systems lost little of their resistance when transferred to environments without antibiotic pressure. Additionally, multidrug-resistant\n            <jats:italic>S<\/jats:italic>\n            . Typhimurium isolates genetically shared relevancy with pathogenic\n            <jats:italic>S<\/jats:italic>\n            . Typhimurium isolates, whereas susceptible isolates clustered with nonpathogenic strains. These results provide detailed discussion and explanation about the genetic alterations and simultaneous acquisition of antibiotic resistance in\n            <jats:italic>S<\/jats:italic>\n            . Typhimurium in agricultural environments.\n          <\/jats:p>","DOI":"10.1128\/aem.01173-18","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T10:11:07Z","timestamp":1532427067000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Alterations of Salmonella enterica Serovar Typhimurium Antibiotic Resistance under Environmental Pressure"],"prefix":"10.1128","volume":"84","author":[{"given":"Mengfei","family":"Peng","sequence":"first","affiliation":[{"name":"Biological Sciences Program\u2014Molecular and Cellular Biology, University of Maryland, College Park, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serajus","family":"Salaheen","sequence":"additional","affiliation":[{"name":"Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, University of Maryland, College Park, Maryland, USA"},{"name":"Center for Food Safety and Security Systems, University of Maryland, College Park, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debabrata","family":"Biswas","sequence":"additional","affiliation":[{"name":"Biological Sciences Program\u2014Molecular and Cellular Biology, University of Maryland, College Park, Maryland, USA"},{"name":"Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA"},{"name":"Center for Food Safety and Security Systems, University of Maryland, College Park, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-2153-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbw141"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2014.02.017"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13282"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2008.0795"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.28"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0804.010312"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/003335491212700103"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-52512-3.00187-X"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2007.31"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-805247-1.00025-3"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01014"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S55778"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/430610"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.7.2054-2059.2001"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.10.6005-6011.2004"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1145"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.7.4205-4210.2004"},{"key":"e_1_3_3_20_2","volume-title":"Antibiotic resistance threats in the United States, 2013","author":"CDC","year":"2013","unstructured":"CDC. 2013. 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