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Unfortunately, 26% of patients die within 5\u2009years of developing these infections.\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            is the bacterium most commonly responsible for this problem and can form biofilms to provide protection from antibiotics as well as the immune system. Although biofilms are evident on the infected implants, it is unclear how these are attached to the surface in the first place. Recent\n            <jats:italic>in vitro<\/jats:italic>\n            investigations have shown that staphylococcal strains rapidly form aggregates in the presence of synovial fluid and provide protection to bacteria, thus allowing them time to attach to the implant surface, leading to biofilm formation. In this study, we investigated the attachment kinetics of\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            aggregates on different orthopedic materials. The information presented in this article will be useful in surgical management and implant design.\n          <\/jats:p>","DOI":"10.1128\/aem.01234-20","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T13:29:41Z","timestamp":1595510981000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["Staphylococcus aureus Aggregates on Orthopedic Materials under Varying Levels of Shear Stress"],"prefix":"10.1128","volume":"86","author":[{"given":"Tripti Thapa","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niraj K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Pestrak","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devendra H.","family":"Dusane","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6463-3515","authenticated-orcid":false,"given":"Janette M.","family":"Harro","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, School of Dentistry, University of Maryland\u2013Baltimore, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5568-0096","authenticated-orcid":false,"given":"Alexander R.","family":"Horswill","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6069-273X","authenticated-orcid":false,"given":"Paul","family":"Stoodley","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA"},{"name":"Department of Orthopedics, The Ohio State University, Columbus, Ohio, USA"},{"name":"National Centre for Advanced Tribology at Southampton and National Biofilm Innovation Centre, Mechanical Engineering, University of Southampton, Southampton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/app9173548"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0702.010226"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.14.64"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0066-782x2011001400018"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2008.12.011"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2014.65"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.00789"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/2309499019847768"},{"key":"e_1_3_3_10_2","volume-title":"Number of all-listed procedures for discharges from short-stay hospitals, by procedure category and age: United States, 2010","author":"Centers for Disease Control and Prevention","year":"2010","unstructured":"Centers for Disease Control and Prevention. 2010. 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