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We showed that\n                      <jats:italic toggle=\"yes\">C. jejuni<\/jats:italic>\n                      Bf survives and actively multiplies under combined thermal and oxidative stress. Stress exposure induces cell rounding, loss of motility, remodeling of membrane composition, decreased membrane fluidity, and metabolic reprogramming with increased intracellular ATP levels. While maintaining the lipid composition of its plasma membrane,\n                      <jats:italic toggle=\"yes\">C. jejuni<\/jats:italic>\n                      modulates the lipid composition of its extracellular vesicles when exposed to stress. Notably, stressed\n                      <jats:italic toggle=\"yes\">C. jejuni<\/jats:italic>\n                      cells release extracellular vesicles with increased toxicity toward the epithelial barrier of Caco-2 cells, potentially facilitating invasion of the gut epithelium.\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        <jats:italic toggle=\"yes\">Campylobacter<\/jats:italic>\n                        infections are one of the leading causes of foodborne gastroenteritis worldwide.\n                        <jats:italic toggle=\"yes\">Campylobacter<\/jats:italic>\n                        readily enters the food chain and is transmitted to humans, primarily through the consumption of contaminated poultry meat. The high prevalence of aerotolerant human\n                        <jats:italic toggle=\"yes\">Campylobacter jejuni<\/jats:italic>\n                        isolates suggests a correlation between their ability to survive under aerobic conditions, virulence, and resistance to harsh stress conditions. However, the underlying mechanism remains unclear. Our results show that\n                        <jats:italic toggle=\"yes\">C. jejuni<\/jats:italic>\n                        extracellular vesicles are part of a survival strategy that links environmental adaptation with pathogenicity.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/aem.01265-26","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:00:36Z","timestamp":1786712436000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Poultry handling-related stress alters membrane composition, extracellular vesicle production, survival, and virulence in\n                    <i>Campylobacter jejuni<\/i>\n                    Bf"],"prefix":"10.1128","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9471-587X","authenticated-orcid":false,"given":"Jeanne","family":"Malet-Villemagne","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, INRAE, AgroParisTech, Micalis Institute","place":["Jouy en Josas, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rochelle","family":"D'Mello","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03c4mmv16","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Chemistry and Biomolecular Sciences, John L. 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