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However, the rise in multidrug-resistant bacteria has diminished their therapeutic efficacy, signaling the dawn of an era beyond antibiotics. The challenge of multidrug resistance in\n              <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n              is particularly critical, with increasing global mortality and resistance rates. Therefore, the development of alternative therapies to antibiotics is urgently needed. Phages, which are natural predators of bacteria, have inherent advantages. However, comprehensive information on\n              <jats:italic>K. pneumoniae<\/jats:italic>\n              phages is lacking in current literature. This review aims to analyze and summarize relevant studies, focusing on the present state of phage therapy for\n              <jats:italic>K. pneumoniae<\/jats:italic>\n              infections. This includes an examination of treatment methodologies, associated challenges, strategies, new phage technologies, clinical trial safety and efficacy, regulatory issues, and future directions for phage therapy development. Enhancing phage technology is crucial for addressing the evolving threat of multidrug-resistant\n              <jats:italic>K. pneumoniae<\/jats:italic>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aem.01353-24","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T13:02:53Z","timestamp":1727701373000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Challenges and opportunities of phage therapy for\n            <i>Klebsiella pneumoniae<\/i>\n            infections"],"prefix":"10.1128","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4499-2995","authenticated-orcid":false,"given":"Xin","family":"Kou","sequence":"first","affiliation":[{"name":"The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China"},{"name":"Department of Clinical Laboratory, The First People\u2019s Hospital of Yunnan Province, Kunming, Yunnan, China"},{"name":"The Affliated Hospital of College of Medical, Kunming University of Science and Technology, Kunming, Yunnan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The First People\u2019s Hospital of Yunnan Province, Kunming, Yunnan, China"},{"name":"The Affliated Hospital of College of Medical, Kunming University of Science and Technology, Kunming, Yunnan, China"},{"name":"Regenerative Medicine Research Center, The First People\u2019s Hospital of Yunnan Province, Kunming, Yunnan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7503-3470","authenticated-orcid":true,"given":"Rui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The First People\u2019s Hospital of Yunnan Province, Kunming, Yunnan, China"},{"name":"The Affliated Hospital of College of Medical, Kunming University of Science and Technology, Kunming, Yunnan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Medical microbiology","author":"Guentzel MN","year":"1996","unstructured":"Guentzel MN. 1996. 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