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Wild rodents are ubiquitous, and those living close to agricultural farms may pose a food safety risk should they shed zoonotic microorganisms in their feces near or on agricultural commodities. Fecal samples from wild rodents trapped on 13 agricultural farms (9 produce, 3 cow-calf operations, and 1 beef cattle feedlot) in Monterey and San Benito Counties, CA, were screened to determine the prevalence and risk factors for shedding of several food-borne pathogens. Deer mice (<jats:named-content content-type=\"genus-species\">Peromyscus maniculatus<\/jats:named-content>) were the most abundant rodent species trapped (72.5%).<jats:named-content content-type=\"genus-species\">Cryptosporidium<\/jats:named-content>species (26.0%) and<jats:named-content content-type=\"genus-species\">Giardia<\/jats:named-content>species (24.2%) were the predominant isolates from rodent feces, followed by<jats:named-content content-type=\"genus-species\">Salmonella enterica<\/jats:named-content>serovars (2.9%) and<jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>O157:H7 (0.2%). Rodent trap success was significantly associated with detection of<jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>in rodent feces, while farm type was associated with fecal shedding of<jats:named-content content-type=\"genus-species\">Cryptosporidium<\/jats:named-content>and<jats:named-content content-type=\"genus-species\">Giardia<\/jats:named-content>. Seasonal shedding patterns were evident, with rodents trapped during the spring and summer months being significantly less likely to be shedding<jats:named-content content-type=\"genus-species\">Cryptosporidium<\/jats:named-content>oocysts than those trapped during autumn. Higher rodent species diversity tended to correlate with lower fecal microbial prevalence, and most spatiotemporal pathogen clusters involved deer mice. Rodents in the study area posed a minimal risk as environmental reservoirs of<jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>O157:H7, but they may play a role in environmental dissemination of<jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>and protozoa. Rodent control efforts that potentially reduce biodiversity may increase pathogen shedding, possibly through promotion of intraspecific microbial transmission.<\/jats:p>","DOI":"10.1128\/aem.01503-13","type":"journal-article","created":{"date-parts":[[2013,8,10]],"date-time":"2013-08-10T01:33:13Z","timestamp":1376098393000},"page":"6337-6344","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":76,"title":["Fecal Shedding of Zoonotic Food-Borne Pathogens by Wild Rodents in a Major Agricultural Region of the Central California Coast"],"prefix":"10.1128","volume":"79","author":[{"given":"Christopher","family":"Kilonzo","sequence":"first","affiliation":[{"name":"Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunde","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo J.","family":"Vivas","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele T.","family":"Jay-Russell","sequence":"additional","affiliation":[{"name":"Western Center for Food Safety, University of California, Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine L.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward R.","family":"Atwill","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, Davis, California, USA"},{"name":"Western Center for Food Safety, University of California, Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jim.7000199"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-4337.2003.tb00031.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-67.10.2342"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268808001969"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/08920750903363190"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001159"},{"key":"e_1_3_2_8_2","first-page":"1","volume-title":"Enteric human pathogens associated with fresh produce: sources, transport, and ecologyMicrobial safety of fresh produce","author":"Mandrell RE","year":"2009","unstructured":"MandrellRE. 2009. 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