{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:01:55Z","timestamp":1791158515121,"version":"4.1.0"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"19","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The persistence of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Listeria monocytogenes<\/jats:named-content>\n            in food processing plants and other ecosystems reflects its ability to adapt to numerous stresses. In this study, we investigated 138 isolates from foods and food processing plants for resistance to the quaternary ammonium disinfectant benzalkonium chloride (BC) and to heavy metals (cadmium and arsenic). We also determined the prevalence of distinct cadmium resistance determinants (\n            <jats:italic>cadA1<\/jats:italic>\n            ,\n            <jats:italic>cadA2<\/jats:italic>\n            , and\n            <jats:italic>cadA3<\/jats:italic>\n            ) among cadmium-resistant isolates. Most BC-resistant isolates were resistant to cadmium as well. Arsenic resistance was encountered primarily in serotype 4b and was an attribute of most isolates of the serotype 4b epidemic clonal group ECIa. Prevalence of the known cadmium resistance determinants was serotype associated:\n            <jats:italic>cadA1<\/jats:italic>\n            was more common in isolates of serotypes 1\/2a and 1\/2b than 4b, while\n            <jats:italic>cadA2<\/jats:italic>\n            was more common in those of serotype 4b. A subset (15\/77 [19%]) of the cadmium-resistant isolates lacked the known cadmium resistance determinants. Most of these isolates were of serotype 4b and were also resistant to arsenic, suggesting novel determinants that may confer resistance to both cadmium and arsenic in these serotype 4b strains. The findings may reflect previously unrecognized components of the ecological history of different serotypes and clonal groups of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">L. monocytogenes<\/jats:named-content>\n            , including exposures to heavy metals and disinfectants.\n          <\/jats:p>","DOI":"10.1128\/aem.01553-12","type":"journal-article","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T11:47:45Z","timestamp":1343476065000},"page":"6938-6945","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":77,"title":["Heavy Metal and Disinfectant Resistance of Listeria monocytogenes from Foods and Food Processing Plants"],"prefix":"10.1128","volume":"78","author":[{"given":"Shakir S.","family":"Ratani","sequence":"first","affiliation":[{"name":"Department of Genomic Sciences, North Carolina State University, Raleigh, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin M.","family":"Siletzky","sequence":"additional","affiliation":[{"name":"Department of Food Science, North Carolina State University, Raleigh, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikrant","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Microbiology, North Carolina State University, Raleigh, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suleyman","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Food Science, North Carolina State University, Raleigh, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason A.","family":"Osborne","sequence":"additional","affiliation":[{"name":"Department of Statistics, North Carolina State University, Raleigh, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Lin","sequence":"additional","affiliation":[{"name":"Food and Drug Administration, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony D.","family":"Hitchins","sequence":"additional","affiliation":[{"name":"Food and Drug Administration College Park, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd J.","family":"Ward","sequence":"additional","affiliation":[{"name":"United States Department of Agriculture, Peoria, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Kathariou","sequence":"additional","affiliation":[{"name":"Department of Food Science, North Carolina State University, Raleigh, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-010-0988-x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2011.01.005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03064-09"},{"key":"e_1_3_2_5_2","first-page":"257","article-title":"Multilocus sequence typing of outbreak-associated Listeria monocytogenes isolates to identify epidemic clones","volume":"7","author":"den Bakker HC","year":"2010","unstructured":"den BakkerHCFortesEDWiedmannM. 2010. Multilocus sequence typing of outbreak-associated Listeria monocytogenes isolates to identify epidemic clones. Appl. Environ. Microbiol.7: 257\u2013 265.","journal-title":"Appl. Environ. Microbiol."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.8.3819-3822.2004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01453-06"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02056-10"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2006.07.008"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-120"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063447"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(00)00501-8"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.67.2.840-847.2001"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-65.11.1811"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2006.3.292"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1139\/w11-062"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02480-08"},{"key":"e_1_3_2_18_2","first-page":"681","volume-title":"Listeria, listeriosis and food safety","author":"Kornacki JL","year":"2007","unstructured":"KornackiJLGurtlerJB. 2007. Incidence and control of Listeria in food processing facilities, p 681\u2013766. InRyserETMarthEH (ed), Listeria, listeriosis and food safety, 3rd ed. CRC Press, Boca Raton, FL.","edition":"3"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012511"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.58.9.3183-3186.1992"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.10.3040-3048.1994"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.10.3049-3061.1994"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2011.03.010"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.1997.00238.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02426-07"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01751-09"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh562"},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1201\/9781420015188.ch4","volume-title":"Listeria, listeriosis and food safety","author":"Painter J","year":"2007","unstructured":"PainterJSlutskerL. 2007. Listeriosis in humans, p 85\u2013109. InRyserETMarthEH (ed), Listeria, listeriosis and food safety, 3rd ed. CRC Press, Boca Raton, FL.","edition":"3"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1701.P11101"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.50.1.753"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.7.2707-2716.1997"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.05356-0"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.7.4158-4164.2004"}],"container-title":["Applied and Environmental Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AEM.01553-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AEM.01553-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T01:29:57Z","timestamp":1645579797000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AEM.01553-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":32,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1128\/AEM.01553-12"],"URL":"https:\/\/doi.org\/10.1128\/aem.01553-12","relation":{},"ISSN":["0099-2240","1098-5336"],"issn-type":[{"value":"0099-2240","type":"print"},{"value":"1098-5336","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"2012-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-07-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-09-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}