{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:17:15Z","timestamp":1790666235599,"version":"4.1.0"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Lyme borreliosis in North America is caused by the tick-borne spirochete\n            <jats:italic>Borrelia burgdorferi<\/jats:italic>\n            , a zoonotic bacterium that is able to persistently infect a wide range of vertebrate species. Given the pronounced strain structure of\n            <jats:italic>B. burgdorferi<\/jats:italic>\n            in the northeastern United States, we asked whether the fitness of the different genotypes varies among susceptible vertebrate hosts. The transmission dynamics of two genetically divergent human isolates of\n            <jats:italic>B. burgdorferi<\/jats:italic>\n            , BL206 and B348, were analyzed experimentally in white-footed mice and in C3H\/HeNCrl mice over a time period of almost 3 months. We found that the initially high transmission efficiency from white-footed mice to ticks declined sharply for isolate B348 but remained considerably high for isolate BL206. In contrast, in C3H\/HeNCrl mice, high transmission efficiency persisted for both isolates. Our findings provide proof-of-principle evidence for intrinsic fitness variation of\n            <jats:italic>B. burgdorferi<\/jats:italic>\n            strains in vertebrate host species, perhaps indicating the beginnings of adaptive radiation.\n          <\/jats:p>","DOI":"10.1128\/aem.01567-07","type":"journal-article","created":{"date-parts":[[2007,11,3]],"date-time":"2007-11-03T00:45:11Z","timestamp":1194050711000},"page":"153-157","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":96,"title":["Fitness Variation of\n            <i>Borrelia burgdorferi<\/i>\n            Sensu Stricto Strains in Mice"],"prefix":"10.1128","volume":"74","author":[{"given":"Kla\u0301ra","family":"Hanincova\u0301","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Public Health, Yale School of Medicine, Yale University, 60 College Street, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas H.","family":"Ogden","sequence":"additional","affiliation":[{"name":"Public Health Agency of Canada, Foodborne, Waterborne and Zoonotic Infections Divisions, Center for Infectious Disease Prevention and Control, Faculty of Veterinary Medicine, Universite\u0301 de Montre\u0301al, C.P. 5000, Saint-Hyacinthe, Que\u0301bec J2S 7C6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Diuk-Wasser","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Yale School of Medicine, Yale University, 60 College Street, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Pappas","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, New York Medical College, Valhalla, New York 10595"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, New York Medical College, Valhalla, New York 10595"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durland","family":"Fish","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Yale School of Medicine, Yale University, 60 College Street, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, New York Medical College, Valhalla, New York 10595"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Kurtenbach","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Yale School of Medicine, Yale University, 60 College Street, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.7.3847"},{"key":"e_1_3_2_3_2","unstructured":"Infectious diseases of humans: dynamic and control. 1991"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2001)087[0032:AOTSRA]2.0.CO;2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.104.028738"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26944-0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.11.6783-6788.2004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/424681"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1987.36.92"},{"key":"e_1_3_2_10_2","first-page":"25","year":"1993","unstructured":"Fish, D. 1993. 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