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However, the rapid emergence of resistant variants during phage treatment has limited the therapeutic applications of phage. According to our\n                    <jats:italic>trans<\/jats:italic>\n                    -complementation,\n                    <jats:italic>ompC<\/jats:italic>\n                    mutation, and phage adsorption efficiency assays, we identified OmpC as the key receptor-binding protein (RBP) for phage GH-K3, which is essential for effective infection. This study revealed that the phage secondary receptor of\n                    <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n                    , OmpC, is the essential RBP not only for phage infecting Gram-negative bacteria, such as\n                    <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n                    and\n                    <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n                    , but also for\n                    <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n                    .\n                  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