{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:47:21Z","timestamp":1791308841211,"version":"4.3.1"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"23","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Colonization by the fungal pathogen\n            <jats:italic>Candida albicans<\/jats:italic>\n            varies significantly, depending upon the pH and availability of oxygen. Because of our interest in extracellular molecules as potential quorum-sensing molecules, we examined the physiological conditions which regulate the production of the aromatic alcohols, i.e., phenethyl alcohol, tyrosol, and tryptophol. The production of these fusel oils has been well studied for\n            <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n            . Our data show that aromatic alcohol yields for\n            <jats:italic>C. albicans<\/jats:italic>\n            are determined by growth conditions. These conditions include the availability of aromatic amino acids, the pH, oxygen levels, and the presence of ammonium salts. For example, for wild-type\n            <jats:italic>C. albicans<\/jats:italic>\n            , tyrosol production varied 16-fold merely with the inclusion of tyrosine or ammonium salts in the growth medium. Aromatic alcohol production also depends on the transcription regulator Aro80p. Our results are consistent with aromatic alcohol production\u2014aromatic transaminases (gene products for\n            <jats:italic>ARO8<\/jats:italic>\n            and\n            <jats:italic>ARO9<\/jats:italic>\n            ), aromatic decarboxylase (\n            <jats:italic>ARO10<\/jats:italic>\n            ), and alcohol dehydrogenase (\n            <jats:italic>ADH<\/jats:italic>\n            )\u2014via the fusel oil pathway. The expression of\n            <jats:italic>ARO8, ARO9<\/jats:italic>\n            , and\n            <jats:italic>ARO10<\/jats:italic>\n            is also pH dependent.\n            <jats:italic>ARO8<\/jats:italic>\n            and\n            <jats:italic>ARO9<\/jats:italic>\n            were alkaline upregulated, while\n            <jats:italic>ARO10<\/jats:italic>\n            was alkaline downregulated. The alkaline-dependent change in expression of\n            <jats:italic>ARO8<\/jats:italic>\n            was Rim101 independent, while the expression of\n            <jats:italic>ARO9<\/jats:italic>\n            was Rim101 dependent.\n          <\/jats:p>","DOI":"10.1128\/aem.01614-08","type":"journal-article","created":{"date-parts":[[2008,10,4]],"date-time":"2008-10-04T01:09:42Z","timestamp":1223082582000},"page":"7211-7218","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":99,"title":["Regulation of Aromatic Alcohol Production in\n            <i>Candida albicans<\/i>"],"prefix":"10.1128","volume":"74","author":[{"given":"Suman","family":"Ghosh","sequence":"first","affiliation":[{"name":"School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588-0666"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bessie W.","family":"Kebaara","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588-0666"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey L.","family":"Atkin","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588-0666"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W.","family":"Nickerson","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588-0666"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00219-06"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.22.6464"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.35.22163"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04350.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2007.00220.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1411806"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401416101"},{"key":"e_1_3_2_9_2","first-page":"39","year":"1981","unstructured":"Cooper, T. 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