{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:22:57Z","timestamp":1790882577726,"version":"4.1.0"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"22","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"JSPS KAKENHI","award":["JP18K08428"],"award-info":[{"award-number":["JP18K08428"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2019,11,15]]},"abstract":"<jats:p>\n            Global spread of CTX-M-type extended-spectrum \u03b2-lactamase (ESBL)-producing\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            is a critical concern in both clinical and community settings. This dominance of CTX-M-type ESBL producers may be largely due to the successful international spread of epidemic clones, as represented by the extraintestinal pathogenic\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            (ExPEC) ST131. Our findings highlight the worrisome presence of diverse\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            clones associated with humans, including ExPEC lineages harboring the most common\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M<\/jats:sub>\n            variants in untreated wastewater samples. Moreover, the chimeric genes\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M-64<\/jats:sub>\n            and\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M-123<\/jats:sub>\n            , which have not yet been identified from human isolates of domestic origin in Japan, were identified. Exposure to untreated wastewater through combined sewer overflow caused by heavy rains derived from abnormal weather change could pose a risk for human health due to ingesting those antimicrobial-resistant bacteria.\n          <\/jats:p>","DOI":"10.1128\/aem.01740-19","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T13:30:35Z","timestamp":1568295035000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Wastewater as a Probable Environmental Reservoir of Extended-Spectrum-\u03b2-Lactamase Genes: Detection of Chimeric \u03b2-Lactamases CTX-M-64 and CTX-M-123"],"prefix":"10.1128","volume":"85","author":[{"given":"Hayato","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Health and Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Nagano, 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