{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:36:17Z","timestamp":1790235377547,"version":"4.1.0"},"reference-count":44,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2020,1,21]]},"abstract":"<jats:p>\n            The number of immunodepressed individuals is increasing, mainly due to the greater life expectancy in immunodepressed patients due to improvements in modern medical treatments. However, this population group is highly susceptible to invasive aspergillosis. This devastating illness, mainly caused by the fungus\n            <jats:named-content content-type=\"genus-species\">Aspergillus fumigatus<\/jats:named-content>\n            , is associated with mortality rates reaching 90%. Treatment options for this disease are currently limited, and a better understanding of\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            genetic regulatory mechanisms is paramount for the design of new strategies to prevent or combat this infection. Our work provides new insight into the regulation of the development, metabolism, and virulence of this important opportunistic pathogen. The transcriptional regulatory gene\n            <jats:italic>hbxA<\/jats:italic>\n            has a profound effect on\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            biology, governing multiple aspects of conidial development. This is relevant since conidia are the main source of inoculum in\n            <jats:named-content content-type=\"genus-species\">Aspergillus<\/jats:named-content>\n            infections. Importantly,\n            <jats:italic>hbxA<\/jats:italic>\n            also regulates the biosynthesis of secondary metabolites and the pathogenicity of this fungus.\n          <\/jats:p>","DOI":"10.1128\/aem.01779-19","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T11:06:42Z","timestamp":1574334402000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["The Transcriptional Regulator HbxA Governs Development, Secondary Metabolism, and Virulence in Aspergillus fumigatus"],"prefix":"10.1128","volume":"86","author":[{"given":"Timothy","family":"Satterlee","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binita","family":"Nepal","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lorber","sequence":"additional","affiliation":[{"name":"Toxalim (Research Centre in Food Toxicology), Universit\u00e9 de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Puel","sequence":"additional","affiliation":[{"name":"Toxalim (Research Centre in Food Toxicology), Universit\u00e9 de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Calvo","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/843763"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00346"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/513943"},{"key":"e_1_3_3_5_2","first-page":"862","article-title":"Infections caused by filamentous fungi in patients with hematologic malignancies. 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