{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:09:49Z","timestamp":1790672989469,"version":"4.1.0"},"reference-count":44,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Invasive serotype 2 (<jats:italic>cps2<\/jats:italic><jats:sup>+<\/jats:sup>) strains of<jats:italic>Streptococcus suis<\/jats:italic>cause meningitis in pigs and humans. Four case reports of<jats:italic>S. suis<\/jats:italic>meningitis in hunters suggest transmission of<jats:italic>S. suis<\/jats:italic>through the butchering of wild boars. Therefore, the objective of this study was to investigate the prevalence of potentially human-pathogenic<jats:italic>S. suis<\/jats:italic>strains in wild boars.<jats:italic>S. suis<\/jats:italic>was isolated from 92% of all tested tonsils (<jats:italic>n<\/jats:italic>= 200) from wild boars. A total of 244<jats:italic>S. suis<\/jats:italic>isolates were genotyped using PCR assays for the detection of serotype-specific genes, the hemolysin gene<jats:italic>sly<\/jats:italic>, and the virulence-associated genes<jats:italic>mrp<\/jats:italic>and<jats:italic>epf<\/jats:italic>. The prevalence of the<jats:italic>cps2<\/jats:italic><jats:sup>+<\/jats:sup>genotype among strains from wild boars was comparable to that of control strains from domestic pig carriers. Ninety-five percent of the<jats:italic>cps2<\/jats:italic><jats:sup>+<\/jats:sup>wild boar strains were positive for<jats:italic>mrp<\/jats:italic>,<jats:italic>sly<\/jats:italic>, and<jats:italic>epf<\/jats:italic>*, the large variant of<jats:italic>epf<\/jats:italic>. Interestingly,<jats:italic>epf<\/jats:italic>* was significantly more frequently detected in<jats:italic>cps2<\/jats:italic><jats:sup>+<\/jats:sup>strains from wild boars than in those from domestic pigs;<jats:italic>epf<\/jats:italic>* is also typically found in European<jats:italic>S. suis<\/jats:italic>isolates from humans, including a meningitis isolate from a German hunter. These results suggest that at least 10% of wild boars in Northwestern Germany carry<jats:italic>S. suis<\/jats:italic>strains that are potentially virulent in humans. Additional amplified fragment length polymorphism analysis supported this hypothesis, since homogeneous clustering of the<jats:italic>epf<\/jats:italic>*<jats:italic>mrp<\/jats:italic><jats:sup>+<\/jats:sup><jats:italic>sly<\/jats:italic><jats:sup>+<\/jats:sup><jats:italic>cps2<\/jats:italic><jats:sup>+<\/jats:sup>strains from wild boars with invasive human and porcine strains was observed.<\/jats:p>","DOI":"10.1128\/aem.01800-06","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T17:24:58Z","timestamp":1170437098000},"page":"711-717","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":50,"title":["Prevalence of<i>Streptococcus suis<\/i>Genotypes in Wild Boars of Northwestern Germany"],"prefix":"10.1128","volume":"73","author":[{"given":"Christoph G.","family":"Baums","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Mikrobiologie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd Josef","family":"Verk\u00fchlen","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Mikrobiologie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Rehm","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Mikrobiologie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana M. 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