{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:29:56Z","timestamp":1791649796805,"version":"4.3.4"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Sasakawa Scientific Research Grant from the japanese science society"},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15650264"],"award-info":[{"award-number":["15650264"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K09940"],"award-info":[{"award-number":["16K09940"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K10027"],"award-info":[{"award-number":["17K10027"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2020,1,7]]},"abstract":"<jats:p>\n            Carbapenemase-producing\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            (CPE) cause severe health care-associated infections, and their increasing prevalence is a serious concern. Recently, natural ecosystems have been recognized as important reservoirs of antibiotic resistance genes. We investigated the prevalence and genetic characteristics of CPE isolated from the environment (hospital sewage and river water) in the Philippines and found several CPE, including\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            and other species, with different carbapenemases. The most prevalent carbapenemase gene type was NDM, which is endemic in clinical settings. This study revealed that isolates belonging to carbapenemase-producing\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            CC10 and\n            <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n            sequence type 147 (ST147), which are often detected in clinical settings, were dominant in the natural environment. Our work here provides a report on the presence and characteristics of CPE in the environment in the Philippines and demonstrates that both hospital sewage and river water are contaminated by CPE strains belonging to clinically important clonal groups.\n          <\/jats:p>","DOI":"10.1128\/aem.01906-19","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T15:18:33Z","timestamp":1573226313000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":58,"title":["Environmental Presence and Genetic Characteristics of Carbapenemase-Producing\n            <i>Enterobacteriaceae<\/i>\n            from Hospital Sewage and River Water in the Philippines"],"prefix":"10.1128","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2509-8513","authenticated-orcid":false,"given":"Yuki","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Microbiology and Infectious 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