{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:22:50Z","timestamp":1789096970366,"version":"build-2803163510"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"22","license":[{"start":{"date-parts":[[2015,11,15]],"date-time":"2015-11-15T00:00:00Z","timestamp":1447545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2015,11,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Two previously uncharacterized potential broad-spectrum mercury (Hg) resistance operons (\n            <jats:italic>mer<\/jats:italic>\n            ) are present on the chromosome of the soil\n            <jats:named-content content-type=\"genus-species\">Alphaproteobacteria<\/jats:named-content>\n            <jats:named-content content-type=\"genus-species\">Xanthobacter autotrophicus<\/jats:named-content>\n            Py2. These operons,\n            <jats:italic>mer1<\/jats:italic>\n            and\n            <jats:italic>mer2<\/jats:italic>\n            , contain two features which are commonly found in\n            <jats:italic>mer<\/jats:italic>\n            operons in the genomes of soil and marine\n            <jats:named-content content-type=\"genus-species\">Alphaproteobacteria<\/jats:named-content>\n            , but are not present in previously characterized\n            <jats:italic>mer<\/jats:italic>\n            operons: a gene for the mercuric reductase (MerA) that encodes an alkylmercury lyase domain typical of those found on the MerB protein, and the presence of an additional gene, which we are calling\n            <jats:italic>merK<\/jats:italic>\n            , with homology to glutathione reductase. Here, we demonstrate that Py2 is resistant to 0.2 \u03bcM inorganic mercury [Hg(II)] and 0.05 \u03bcM methylmercury (MeHg). Py2 is capable of converting MeHg and Hg(II) to elemental mercury [Hg(0)], and reduction of Hg(II) is induced by incubation in sub toxic concentrations of Hg(II). Transcription of the\n            <jats:italic>merA<\/jats:italic>\n            genes increased with Hg(II) treatment, and in both operons\n            <jats:italic>merK<\/jats:italic>\n            resides on the same polycistronic mRNA as\n            <jats:italic>merA<\/jats:italic>\n            . We propose the use of Py2 as a model system for studying the contribution of\n            <jats:italic>mer<\/jats:italic>\n            to Hg mobility in soil and marine ecosystems.\n          <\/jats:p>","DOI":"10.1128\/aem.01982-15","type":"journal-article","created":{"date-parts":[[2015,9,5]],"date-time":"2015-09-05T02:39:35Z","timestamp":1441420775000},"page":"7833-7838","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["Mercury Reduction and Methyl Mercury Degradation by the Soil Bacterium Xanthobacter autotrophicus Py2"],"prefix":"10.1128","volume":"81","author":[{"given":"Amanda K.","family":"Petrus","sequence":"first","affiliation":[{"name":"Clark University Department of Biology, Worcester, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Rutner","sequence":"additional","affiliation":[{"name":"Clark University Department of Biology, Worcester, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songnian","family":"Liu","sequence":"additional","affiliation":[{"name":"Clark University Department of Biology, Worcester, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Clark University Department of Biology, Worcester, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather A.","family":"Wiatrowski","sequence":"additional","affiliation":[{"name":"Clark University Department of Biology, Worcester, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10653-004-1308-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1579\/0044-7447(2007)36[3:MEAHEI]2.0.CO;2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/20016491089226"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1289\/ehp.1003012","article-title":"Evaluation of the cardiovascular effects of methylmercury exposures: current evidence supports development of a dose-response function for regulatory benefits analysis","volume":"119","author":"Roman HA","year":"2011","unstructured":"Roman HA, Walsh TL, Coull BA, Dewailly \u00c8 Guallar E, Hattis D, Mari\u00ebn K, Schwartz J, Stern AH, Virtanen JK, Rice G. 2011. 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