{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:41:03Z","timestamp":1791848463436,"version":"4.3.4"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"National Key Biosafety Technology Research and Development Program of China","award":["2017YFC1200404-4"],"award-info":[{"award-number":["2017YFC1200404-4"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672071"],"award-info":[{"award-number":["81672071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2020,1,21]]},"abstract":"<jats:p>\n                    <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n                    is an important pathogen that can be widely distributed in the community and clinical settings. The emergence of\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    with multiple-antibiotic resistance has complicated staphylococcal infection control. The development of alternative strategies with powerful bactericidal effects is urgently needed. Cold atmospheric plasma (CAP) is a promising strategy for microorganism inactivation. Nevertheless, the underlying mechanisms of microbial inactivation or resistance are not completely illustrated. In this study, we validated the bactericidal effects of CAP on\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    , including antibiotic-resistant strains. We also found that the golden staphyloxanthin, as well as its yellow pigment intermediates, protected\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    against CAP, and blocking the staphyloxanthin synthesis pathway at the early steps could strengthen the sensitivity of\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    to CAP treatment. These data provide insights into the germicidal mechanism of CAP from the aspect of bacteria and suggest new targets against\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    infections.\n                  <\/jats:p>","DOI":"10.1128\/aem.01998-19","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T05:47:11Z","timestamp":1573451231000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":44,"title":["Protective Effect of the Golden Staphyloxanthin Biosynthesis Pathway on Staphylococcus aureus under Cold Atmospheric Plasma Treatment"],"prefix":"10.1128","volume":"86","author":[{"given":"Yi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Microbiology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University), Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Tsinghua University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huyue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University), Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilong","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University), Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University), Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huagang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University), Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University), Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University), Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, Tsinghua University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiancai","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University), Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"1","article-title":"An update on clinical burden, diagnostic tools, and therapeutic options of Staphylococcus aureus","volume":"10","author":"Reddy PN","year":"2017","unstructured":"Reddy PN, Srirama K, Dirisala SV. 2017. 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