{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:29:55Z","timestamp":1781324995459,"version":"3.54.1"},"reference-count":45,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"South African National Research Foundation","award":["85595"],"award-info":[{"award-number":["85595"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>\n                    Carbapenem-resistant\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    (CRE)-mediated infections remain a significant public health concern and have been reported to be critical in the World Health Organization\u2019s priority pathogens list for the research and development of new antibiotics. CRE produce enzymes, such as metallo-\u03b2-lactamases (MBLs), which inactivate \u03b2-lactam antibiotics. Combination therapies involving a \u03b2-lactam antibiotic and a \u03b2-lactamase inhibitor remain a major treatment option for infections caused by \u03b2-lactamase-producing organisms. Currently, no MBL inhibitor\u2013\u03b2-lactam combination therapy is clinically available for MBL-positive bacterial infections. Hence, developing efficient molecules capable of inhibiting these enzymes could be a promising way to overcome this phenomenon. TACN played a significant role in the inhibitory activity of the tested molecules against CREs by potentiating the activity of carbapenem. This study demonstrates that TACN inhibits MBLs efficiently and holds promises as a potential MBL inhibitor to help curb the global health threat posed by MBL-producing CREs.\n                  <\/jats:p>","DOI":"10.1128\/aem.02077-18","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T06:55:56Z","timestamp":1543301756000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["1,4,7-Triazacyclononane Restores the Activity of \u03b2-Lactam Antibiotics against Metallo-\u03b2-Lactamase-Producing\n                    <i>Enterobacteriaceae<\/i>\n                    : Exploration of Potential Metallo-\u03b2-Lactamase Inhibitors"],"prefix":"10.1128","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1085-7740","authenticated-orcid":false,"given":"Anou M.","family":"Somboro","sequence":"first","affiliation":[{"name":"Antimicrobial Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa"},{"name":"Biomedical Resource Unit, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3551-3458","authenticated-orcid":false,"given":"Daniel G.","family":"Amoako","sequence":"additional","affiliation":[{"name":"Antimicrobial Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa"},{"name":"Biomedical Resource Unit, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9508-984X","authenticated-orcid":false,"given":"John","family":"Osei Sekyere","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hezekiel M.","family":"Kumalo","sequence":"additional","affiliation":[{"name":"Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Khan","sequence":"additional","affiliation":[{"name":"Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A.","family":"Bester","sequence":"additional","affiliation":[{"name":"Biomedical Resource Unit, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabiha Y.","family":"Essack","sequence":"additional","affiliation":[{"name":"Antimicrobial Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2005.08.016"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/2277-8632.108504"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01710336"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00228"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-003-2471-0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.7.2347-2349.2004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.2.306-325.2005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.5b00033"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir202"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2015.0053"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2016.00209"},{"key":"e_1_3_2_13_2","volume-title":"Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics","author":"World Health Organization","year":"2017","unstructured":"World Health Organization. 2017. 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