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An important challenge associated with\n                    <jats:named-content content-type=\"genus-species\">E. faecalis<\/jats:named-content>\n                    infection is the emergence of multidrug-tolerant strains, which have normal MICs but do not respond to antibiotic treatment. Here, we report a strain of\n                    <jats:named-content content-type=\"genus-species\">E. faecalis<\/jats:named-content>\n                    that was isolated from a cystic fibrosis patient and demonstrated high-level tolerance to ampicillin, vancomycin, and tetracycline. Whole-genome sequencing revealed critical substitutions in one of the tetracycline efflux pump repressors that are consistent with the increased tolerance of\n                    <jats:named-content content-type=\"genus-species\">E. faecalis<\/jats:named-content>\n                    UM001B to tetracycline. 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