{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:39:19Z","timestamp":1790732359530,"version":"4.1.0"},"reference-count":55,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000183","name":"DOD | United States Army | RDECOM | Army Research Office","doi-asserted-by":"publisher","award":["W911NF1410318"],"award-info":[{"award-number":["W911NF1410318"]}],"id":[{"id":"10.13039\/100000183","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000183","name":"DOD | United States Army | RDECOM | Army Research Office","doi-asserted-by":"publisher","award":["W911NF1210321"],"award-info":[{"award-number":["W911NF1210321"]}],"id":[{"id":"10.13039\/100000183","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2019,1,15]]},"abstract":"<jats:p>\n            In one of the most well-studied organisms in the life sciences,\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            , we still do not fully understand what causes populations to die. This is largely due to the technological difficulties of studying bacterial cell death. This study provides an avenue to studying how and why\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            populations, and perhaps other microbes, transition from stationary phase to death phase by exploring how ethanol and other alcohols delay the onset of death. Here, we demonstrate that alcohols are acting as signaling molecules to achieve the delay in death phase. This study not only offers a better understanding of a fundamental process but perhaps also provides a gateway to studying the dynamics between ethanol and microbes in the human gastrointestinal tract.\n          <\/jats:p>","DOI":"10.1128\/aem.02113-18","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T11:27:57Z","timestamp":1541417277000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Physiological, Genetic, and Transcriptomic Analysis of Alcohol-Induced Delay of\n            <i>Escherichia coli<\/i>\n            Death"],"prefix":"10.1128","volume":"85","author":[{"given":"Christina M.","family":"Ferraro","sequence":"first","affiliation":[{"name":"Molecular and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Finkel","sequence":"additional","affiliation":[{"name":"Molecular and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1340"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2010.00213.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3136"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.12.6059"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jobm.201600247"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.570"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03150-13"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00722-15"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msx118"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2012.57"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.11.2898-2905.2002"},{"key":"e_1_3_3_13_2","unstructured":"Lazar S. 1996. Survival of Escherichia coli in stationary phase. PhD thesis. Harvard University Cambridge MA."},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.24.7044-7052.2003"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)84512-X"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2333"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1401853111"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-579"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.103.034280"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.125.2.670-678.1976"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.144.2.481-488.1980"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/ecosalplus.3.4.4"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7681219"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/msb4100050"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.120163297"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1210309109"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.157.2.690-693.1984"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jim.2900496"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00755-16"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.14.4482-4492.1991"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)91902-2"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1999.00323.x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02101757"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1209002109"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807157106"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.099"},{"key":"e_1_3_3_37_2","volume-title":"The cell: a molecular approach","author":"Cooper GM","year":"2000","unstructured":"Cooper GM. 2000. The cell: a molecular approach, 2nd ed. Sinauer Associates, Sunderland, MA.","edition":"2"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2009.08.014"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-090110-102946"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.66.3.373-395.2002"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.14.4474-4481.1991"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.24.7571-7579.1999"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001573"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep44150"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13068-016-0527-9"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/26.8.831"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2012.08.002"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750025057"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0359-2"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12626"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12704"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.3.1745"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2009.01526.x"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.016"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp120"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"}],"container-title":["Applied and Environmental Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AEM.02113-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AEM.02113-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T18:58:49Z","timestamp":1645642729000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AEM.02113-18"}},"subtitle":[],"editor":[{"given":"Maia","family":"Kivisaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,1,15]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,1,15]]}},"alternative-id":["10.1128\/AEM.02113-18"],"URL":"https:\/\/doi.org\/10.1128\/aem.02113-18","relation":{},"ISSN":["0099-2240","1098-5336"],"issn-type":[{"value":"0099-2240","type":"print"},{"value":"1098-5336","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,15]]},"assertion":[{"value":"2018-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02113-18"}}