{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:54:06Z","timestamp":1790045646076,"version":"4.0.1"},"reference-count":63,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Norwegian surveillance system for antibiotic resistance in microbes"},{"name":"Nansen funds for research"},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["241011"],"award-info":[{"award-number":["241011"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2019,1,15]]},"abstract":"<jats:p>\n            Bacteria secrete signal molecules into the environment which are sensed by other cells when the density reaches a certain threshold. In this study, we describe a communication system in\n            <jats:named-content content-type=\"genus-species\">Streptococcus mitis<\/jats:named-content>\n            , a commensal species from the oral cavity, which we also found in several species and strains of streptococci from the mitis group. Further, we show that this system can promote cross-communication with\n            <jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>\n            , a closely related major human pathogen. Importantly, we show that this cross-communication can take place during coculture. While the genes regulated in\n            <jats:named-content content-type=\"genus-species\">S. mitis<\/jats:named-content>\n            are likely part of a futile cycle of activation, the target genes in\n            <jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>\n            are potentially involved in virulence. The understanding of such complex communication networks can provide important insights into the dynamics of bacterial communities.\n          <\/jats:p>","DOI":"10.1128\/aem.02297-18","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T09:59:22Z","timestamp":1541066362000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Characterization of a Signaling System in Streptococcus mitis That Mediates Interspecies Communication with Streptococcus pneumoniae"],"prefix":"10.1128","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5538-1088","authenticated-orcid":false,"given":"R.","family":"Junges","sequence":"first","affiliation":[{"name":"Institute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Stur\u00f8d","sequence":"additional","affiliation":[{"name":"Institute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Salvadori","sequence":"additional","affiliation":[{"name":"Institute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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