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According to our results, the combination of honokiol and polymyxin had a clear synergistic effect against MCR-1-positive\n            <jats:italic>Enterobacteriaceae in vitro<\/jats:italic>\n            . Combination therapy also showed a powerful therapeutic effect\n            <jats:italic>in vivo<\/jats:italic>\n            , which can significantly improve mouse livability, reduced the load of bacteria, and reduced pathological change. This combined therapy of small molecule compounds and antibiotics may not continue to induce new bacterial resistance, due to the fact that MCR-1 targeted by honokiol is not indispensable for the bacterial viability; on the other hand, it can reduce the dosage of combined antibiotics, and it is also a promising alternative therapy for the treatment of drug-resistant infections in the future.\n          <\/jats:p>","DOI":"10.1128\/aem.02346-19","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T13:29:01Z","timestamp":1577107741000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Honokiol Restores Polymyxin Susceptibility to MCR-1-Positive Pathogens both\n            <i>In Vitro<\/i>\n            and\n            <i>In Vivo<\/i>"],"prefix":"10.1128","volume":"86","author":[{"given":"Yan","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Respiratory 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