{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T19:40:00Z","timestamp":1792870800025,"version":"4.5.0"},"reference-count":56,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:00:00Z","timestamp":1550188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100008370","name":"National Pork Board","doi-asserted-by":"publisher","award":["16-123"],"award-info":[{"award-number":["16-123"]}],"id":[{"id":"10.13039\/100008370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2019,2,15]]},"abstract":"<jats:p>\n                    <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n                    spp. are an important cause of foodborne illness in North America, and pork products are associated with sporadic cases and outbreaks of human salmonellosis. Isolates of\n                    <jats:italic>Salmonella<\/jats:italic>\n                    may be resistant to multiple antibiotics, and infections with multidrug-resistant (MDR)\n                    <jats:italic>Salmonella<\/jats:italic>\n                    spp. are more difficult to treat, leading to increased hospitalization rates. Swine operations commonly use antimicrobials, such as chlortetracycline, to prevent\/treat infections, which may have collateral effects on pig microbial populations. Recently, we demonstrated that chlortetracycline induces the expression of genes associated with pathogenesis and invasion in MDR\n                    <jats:named-content content-type=\"genus-species\">Salmonella enterica<\/jats:named-content>\n                    serovar Typhimurium\n                    <jats:italic>in vitro<\/jats:italic>\n                    . In our current study, we show increased tonsillar colonization and fecal shedding of the MDR\n                    <jats:named-content content-type=\"genus-species\">S<\/jats:named-content>\n                    . Typhimurium strain DT104 from pigs administered chlortetracycline. Therefore, pigs unknowingly colonized with multidrug-resistant\n                    <jats:italic>Salmonella<\/jats:italic>\n                    spp. and receiving chlortetracycline for an unrelated infection may be at a greater risk for disseminating MDR\n                    <jats:italic>Salmonella<\/jats:italic>\n                    spp. to other pigs and to humans through environmental or pork product contamination.\n                  <\/jats:p>","DOI":"10.1128\/aem.02354-18","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T06:13:28Z","timestamp":1544076808000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Chlortetracycline Enhances Tonsil Colonization and Fecal Shedding of Multidrug-Resistant\n                    <i>Salmonella enterica<\/i>\n                    Serovar Typhimurium DT104 without Major Alterations to the Porcine Tonsillar and Intestinal Microbiota"],"prefix":"10.1128","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5306-3732","authenticated-orcid":false,"given":"Devin B.","family":"Holman","sequence":"first","affiliation":[{"name":"Food Safety and Enteric Pathogens Research Unit, National Animal Disease Center, ARS, USDA, Ames, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley L.","family":"Bearson","sequence":"additional","affiliation":[{"name":"Agroecosystems Management Research Unit, National Laboratory for Agriculture and the Environment, ARS, USDA, Ames, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather K.","family":"Allen","sequence":"additional","affiliation":[{"name":"Food Safety and Enteric Pathogens Research Unit, National Animal Disease Center, ARS, USDA, Ames, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Shippy","sequence":"additional","affiliation":[{"name":"Food Safety and Enteric Pathogens Research Unit, National Animal Disease Center, ARS, USDA, Ames, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal L.","family":"Loving","sequence":"additional","affiliation":[{"name":"Food Safety and Enteric Pathogens Research Unit, National Animal Disease Center, ARS, USDA, Ames, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Kerr","sequence":"additional","affiliation":[{"name":"Agroecosystems Management Research Unit, National Laboratory for Agriculture and the Environment, ARS, USDA, Ames, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn M. 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