{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:13:32Z","timestamp":1790669612792,"version":"4.1.0"},"reference-count":66,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A_175557"],"award-info":[{"award-number":["31003A_175557"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_200706"],"award-info":[{"award-number":["310030_200706"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2022,3,8]]},"abstract":"<jats:p>\n                    Environmental bacteria of the genus\n                    <jats:italic>Legionella<\/jats:italic>\n                    are the causative agents of the severe pneumonia Legionnaires\u2019 disease, the incidence of which is on the rise worldwide.\n                    <jats:named-content content-type=\"genus-species\">Legionella pneumophila<\/jats:named-content>\n                    and\n                    <jats:named-content content-type=\"genus-species\">Legionella longbeachae<\/jats:named-content>\n                    are the most clinically relevant species. The opportunistic pathogens are inhaled through contaminated aerosols and replicate in human lung macrophages with a mechanism similar to that in their natural hosts, free-living amoebae.\n                  <\/jats:p>","DOI":"10.1128\/aem.02370-21","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T16:56:27Z","timestamp":1641401787000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["The\n                    <i>Legionella<\/i>\n                    Lqs-LvbR Regulatory Network Controls Temperature-Dependent Growth Onset and Bacterial Cell Density"],"prefix":"10.1128","volume":"88","author":[{"given":"Ramon","family":"Hochstrasser","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, University of Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5462-9301","authenticated-orcid":true,"given":"Hubert","family":"Hilbi","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, University of Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00052-09"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1758-2229.2011.00247.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.002786"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00477"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12235"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00061"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100913-013439"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2015.1"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.02.003"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-102215-095557"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2017.08.004"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.67"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2009.02025.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141121660"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2007\/008698-0"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.15.21"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00125"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.128678"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.570085"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01018-16"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13313"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.170149"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2010.08.016"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12326"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04129.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2013_346"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2010.03.004"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00079"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801929200"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13265"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01002-08"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/s120302899"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2012.02889.x"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.4161\/rna.20270"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2010.02167.x"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.01005.x"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12612"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14477"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.14523"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2020.01.001"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07259.x"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1080\/08927014.2016.1212988"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2017.11.010"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005307"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13021-8"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-020-00774-0"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202152972"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evab032"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000851"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03132-14"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24263-9"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01519.x"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.1.67-75.2002"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06555.x"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.7.3029-3034.1998"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.16.4879-4889.1999"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.02884.x"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0882-4010(03)00027-5"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1097(03)00050-8"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006629"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01077-13"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00316-10"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.10.4.437-441.1979"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.4.1319"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.12.5361-5373.1993"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.72.4.2885-2895.2006"}],"container-title":["Applied and Environmental Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aem.02370-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aem.02370-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T11:24:29Z","timestamp":1646738669000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aem.02370-21"}},"subtitle":[],"editor":[{"given":"Maia","family":"Kivisaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,3,8]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,3,8]]}},"alternative-id":["10.1128\/aem.02370-21"],"URL":"https:\/\/doi.org\/10.1128\/aem.02370-21","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.10.12.464170","asserted-by":"object"}]},"ISSN":["0099-2240","1098-5336"],"issn-type":[{"value":"0099-2240","type":"print"},{"value":"1098-5336","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,8]]},"assertion":[{"value":"2021-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02370-21"}}