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Discovering new natural products and modifying known compounds are still the two main ways to generate new candidates. Here, we have discovered several rifamycins with varied skeleton structures by redirecting the metabolic flux from the predominant polyketide biosynthetic pathway to the rifamycin pathway in the marine actinomycetes species\n            <jats:italic>Micromonospora<\/jats:italic>\n            sp. strain TP-A0468. Rifamycins are indispensable chemotherapeutics in the treatment of various diseases such as tuberculosis, leprosy, and AIDS-related mycobacterial infections. This study exemplifies a useful method for the discovery of cryptic natural products in genome-sequenced microbes. Moreover, the 16-demethylrifamycins and their genetically manipulable producer provide a new opportunity in the construction of novel rifamycin derivates to aid in the defense against the ever-growing drug resistance of\n            <jats:named-content content-type=\"genus-species\">Mycobacterium tuberculosis<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/aem.02597-18","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T09:36:26Z","timestamp":1544434586000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Discovery of 16-Demethylrifamycins by Removing the Predominant Polyketide Biosynthesis Pathway in\n            <i>Micromonospora<\/i>\n            sp. 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