{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:35:19Z","timestamp":1787495719348,"version":"build-2736575974"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100001655","name":"Grayson-Jockey Club Research Foundation","doi-asserted-by":"publisher","award":["A201509024Y1A0"],"award-info":[{"award-number":["A201509024Y1A0"]}],"id":[{"id":"10.13039\/100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>\n                    This work advances our understanding of the opportunistic environmental pathogen\n                    <jats:named-content content-type=\"genus-species\">Rhodococcus equi<\/jats:named-content>\n                    , a disease agent affecting horses and immunocompromised people.\n                    <jats:named-content content-type=\"genus-species\">R. equi<\/jats:named-content>\n                    is one of the most common causes of severe pneumonia in young horses. For decades, the standard treatment for\n                    <jats:named-content content-type=\"genus-species\">R. equi<\/jats:named-content>\n                    pneumonia in horses has been dual antimicrobial therapy with a macrolide and rifampin; effective alternatives to this combination are lacking. The World Health Organization classifies these antimicrobial agents as critically important for human medicine. Widespread macrolide and rifampin resistance in\n                    <jats:named-content content-type=\"genus-species\">R. equi<\/jats:named-content>\n                    isolates is a major emerging problem for the horse-breeding industry and might also adversely impact human health if resistant strains infect people or transfer resistance mechanisms to other pathogens. This study details the impact of antimicrobial resistance on\n                    <jats:named-content content-type=\"genus-species\">R. equi<\/jats:named-content>\n                    fitness, a vital step for understanding the ecology and epidemiology of resistant\n                    <jats:named-content content-type=\"genus-species\">R. equi<\/jats:named-content>\n                    isolates, and will support development of novel strategies to combat antimicrobial resistance.\n                  <\/jats:p>","DOI":"10.1128\/aem.02665-18","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T10:36:13Z","timestamp":1548239773000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Effect of Macrolide and Rifampin Resistance on the Fitness of Rhodococcus equi"],"prefix":"10.1128","volume":"85","author":[{"given":"Jennifer M.","family":"Willingham-Lane","sequence":"first","affiliation":[{"name":"Department of Large Animal Medicine, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Londa J.","family":"Berghaus","sequence":"additional","affiliation":[{"name":"Department of Large Animal Medicine, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy D.","family":"Berghaus","sequence":"additional","affiliation":[{"name":"Department of Population Health, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey A.","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Large Animal Medicine, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steeve","family":"Gigu\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Large Animal Medicine, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2014.11.004"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2014.08.010"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.72.7.945"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"510","DOI":"10.2460\/javma.1998.213.04.510","article-title":"Associations between physical examination, laboratory, and radiographic findings and outcome and subsequent racing performance of foals with Rhodococcus equi infection: 115 cases (1984-1992)","volume":"213","author":"Ainsworth DM","year":"1998","unstructured":"Ainsworth DM, Eicker SW, Yeagar AE, Sweeney CR, Viel L, Tesarowski D, Lavoie JP, Hoffman A, Paradis MR, Reed SM, Erb HN, Davidow E, Nalevanko M. 1998. 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