{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:32:51Z","timestamp":1791304371459,"version":"4.3.1"},"reference-count":68,"publisher":"American Society for Microbiology","issue":"19","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Listeria monocytogenes<\/jats:italic>\n            is a food-borne, opportunistic, bacterial pathogen causing a wide spectrum of diseases, including meningitis, septicemia, abortion, and gastroenteritis, in humans and animals. Among the 13\n            <jats:italic>L. monocytogenes<\/jats:italic>\n            serovars described, human listeriosis is mostly associated with strains of serovars 4b, 1\/2b, and 1\/2a. Within the species\n            <jats:italic>L. monocytogenes<\/jats:italic>\n            , three phylogenetic lineages are described. Serovar 1\/2a belongs to phylogenetic lineage I, while serovars 4b and 1\/2b group in phylogenetic lineage II. To explore the role of gene expression in the adaptation of\n            <jats:italic>L. monocytogenes<\/jats:italic>\n            strains of these two major lineages to different environments, as well as in virulence, we performed whole-genome expression profiling of six\n            <jats:italic>L. monocytogenes<\/jats:italic>\n            isolates of serovars 4b, 1\/2b, and 1\/2a of distinct origins, using a newly constructed\n            <jats:italic>Listeria<\/jats:italic>\n            multigenome DNA array. Comparison of the global gene expression profiles revealed differences among strains. The expression profiles of two strains having distinct 50% lethal doses, as assessed in the mouse model, were further analyzed. Gene ontology term enrichment analysis of the differentially expressed genes identified differences in protein-, nucleic acid-, carbon metabolism-, and virulence-related gene expression. Comparison of the expression profiles of the core genomes of all strains revealed differences between the two lineages with respect to cell wall synthesis, the stress-related sigma B regulon and virulence-related genes. These findings suggest different patterns of interaction with host cells and the environment, key factors for host colonization and survival in the environment.\n          <\/jats:p>","DOI":"10.1128\/aem.02730-06","type":"journal-article","created":{"date-parts":[[2007,8,18]],"date-time":"2007-08-18T00:54:39Z","timestamp":1187398479000},"page":"6078-6088","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":59,"title":["Comparative Transcriptome Analysis of\n            <i>Listeria monocytogenes<\/i>\n            Strains of the Two Major Lineages Reveals Differences in Virulence, Cell Wall, and Stress Response"],"prefix":"10.1128","volume":"73","author":[{"given":"Patricia","family":"Severino","sequence":"first","affiliation":[{"name":"Unite\u0301 de Ge\u0301nomique des Microorganismes Pathoge\u0300nes and CNRS URA 2171"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Dussurget","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Interactions Bacte\u0301ries-Cellules, Institut Pasteur, 25-28 Rue du Docteur Roux, 75724 Paris Cedex 15, France"},{"name":"INSERM U604, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France"},{"name":"INRA USC2020, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Z. N.","family":"Ve\u0302ncio","sequence":"additional","affiliation":[{"name":"Computational Biology Group, Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Dumas","sequence":"additional","affiliation":[{"name":"UR484 Microbiologie, Equipe Qualite\u0301 et Se\u0301curite\u0301 des Aliments (QuaSA), INRA de Clermont-Ferrand\/Theix, F-63122 Saint-Gene\u0300s Champanelle, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Garrido","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Ge\u0301nomique des Microorganismes Pathoge\u0300nes and CNRS URA 2171"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Padilla","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Instituto de Cie\u0302ncias Biome\u0301dicas da Universidade de Sa\u0303o Paulo, 05508-900 Sa\u0303o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Piveteau","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie, INRA UMR1232, 1 Esplanade Erasme, F-21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Lemai\u0302tre","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie, INRA UMR1232, 1 Esplanade Erasme, F-21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Kunst","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Ge\u0301nomique des Microorganismes Pathoge\u0300nes and CNRS URA 2171"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Glaser","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Ge\u0301nomique des Microorganismes Pathoge\u0300nes and CNRS URA 2171"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Buchrieser","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Ge\u0301nomique des Microorganismes Pathoge\u0300nes and CNRS URA 2171"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.7.4657-4660.2001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.9.5530-5539.2005"},{"key":"e_1_3_2_4_2","first-page":"134","volume":"22","year":"1938","unstructured":"Bliss, C. 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