{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:13:13Z","timestamp":1790244793330,"version":"4.1.0"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP15K07358"],"award-info":[{"award-number":["JP15K07358"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In streptomycetes, autoregulators are important signaling compounds that trigger secondary metabolism, and they are regarded as\n            <jats:named-content content-type=\"genus-species\">Streptomyces<\/jats:named-content>\n            hormones based on their extremely low effective concentrations (nM) and the involvement of specific receptor proteins. Our previous distribution study revealed that butenolide-type\n            <jats:named-content content-type=\"genus-species\">Streptomyces<\/jats:named-content>\n            hormones, including avenolide, are a general class of signaling molecules in streptomycetes and that\n            <jats:named-content content-type=\"genus-species\">Streptomyces albus<\/jats:named-content>\n            strain J1074 may produce butenolide-type\n            <jats:named-content content-type=\"genus-species\">Streptomyces<\/jats:named-content>\n            hormones. Here, we describe metabolite profiling of a disruptant of the\n            <jats:named-content content-type=\"genus-species\">S. albus<\/jats:named-content>\n            <jats:italic>aco<\/jats:italic>\n            gene, which encodes a key biosynthetic enzyme for butenolide-type\n            <jats:named-content content-type=\"genus-species\">Streptomyces<\/jats:named-content>\n            hormones, and identify four butenolide compounds from\n            <jats:named-content content-type=\"genus-species\">S. albus<\/jats:named-content>\n            J1074 that show avenolide activity. The compounds structurally resemble avenolide and show different levels of avenolide activity. A dual-culture assay with imaging mass spectrometry (IMS) analysis for\n            <jats:italic>in vivo<\/jats:italic>\n            metabolic profiling demonstrated that the butenolide compounds of\n            <jats:named-content content-type=\"genus-species\">S. albus<\/jats:named-content>\n            J1074 stimulate avermectin production in another\n            <jats:named-content content-type=\"genus-species\">Streptomyces<\/jats:named-content>\n            species,\n            <jats:named-content content-type=\"genus-species\">Streptomyces avermitilis<\/jats:named-content>\n            , illustrating the complex chemical interactions through interspecies signals in streptomycetes.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>IMPORTANCE<\/jats:bold>\n            Microorganisms produce external and internal signaling molecules to control their complex physiological traits. In actinomycetes,\n            <jats:named-content content-type=\"genus-species\">Streptomyces<\/jats:named-content>\n            hormones are low-molecular-weight signals that are key to our understanding of the regulatory mechanisms of\n            <jats:named-content content-type=\"genus-species\">Streptomyces<\/jats:named-content>\n            secondary metabolism. This study reveals that acyl coenzyme A (acyl-CoA) oxidase is a common and essential biosynthetic enzyme for butenolide-type\n            <jats:named-content content-type=\"genus-species\">Streptomyces<\/jats:named-content>\n            hormones. Moreover, the diffusible butenolide compounds from a donor\n            <jats:named-content content-type=\"genus-species\">Streptomyces<\/jats:named-content>\n            strain were recognized by the recipient\n            <jats:named-content content-type=\"genus-species\">Streptomyces<\/jats:named-content>\n            strain of a different species, resulting in the initiation of secondary metabolism in the recipient. This is an interesting report on the chemical interaction between two different streptomycetes via\n            <jats:named-content content-type=\"genus-species\">Streptomyces<\/jats:named-content>\n            hormones. Information on the metabolite network may provide useful hints not only to clarification of the regulatory mechanism of secondary metabolism, but also to understanding of the chemical communication among streptomycetes to control their physiological traits.\n          <\/jats:p>","DOI":"10.1128\/aem.02791-17","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T11:10:06Z","timestamp":1519729806000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Butenolides from Streptomyces albus J1074 Act as External Signals To Stimulate Avermectin Production in Streptomyces avermitilis"],"prefix":"10.1128","volume":"84","author":[{"given":"Thao Bich","family":"Nguyen","sequence":"first","affiliation":[{"name":"International Center for Biotechnology, Osaka University, Suita, Osaka Prefecture, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kitani","sequence":"additional","affiliation":[{"name":"International Center for Biotechnology, Osaka University, Suita, Osaka Prefecture, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Shimma","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka Prefecture, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Nihira","sequence":"additional","affiliation":[{"name":"International Center for Biotechnology, Osaka University, Suita, Osaka Prefecture, Japan"},{"name":"MU-OU Collaborative Research Center for Bioscience and Biotechnology, Faculty of Science, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2005.02.016"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1324253111"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01337-10"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2006.04.003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuw012"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1113908108"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-016-7781-4"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2017.85"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-010-0730-9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08447.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-014-5523-z"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-013-5440-6"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.12116"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-97"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13479"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2014.151"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/md12020799"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/np000599g"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/md12063323"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10316-y"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2009.08.010"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12752"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.28139-0"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b02716"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.18.4929-4937.1998"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.048371-0"},{"key":"e_1_3_3_28_2","doi-asserted-by":"crossref","unstructured":"Paget MSB Chamberlin L Atrih A Foster SJ Buttner MJ. 1999. 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