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However, additional elements participating in the integrative pathway remain to be identified. In\n            <jats:named-content content-type=\"genus-species\">Trichoderma<\/jats:named-content>\n            <jats:italic>atroviride<\/jats:italic>\n            , the blue-light regulator (BLR) proteins BLR-1 and -2 are known to regulate gene transcription, mycelial growth, and asexual development upon illumination, and recent global transcriptional analysis revealed that the histone deacetylase-encoding gene\n            <jats:italic>hda-2<\/jats:italic>\n            is induced by light. Here, by assessing responses to stimuli in wild-type and \u0394\n            <jats:italic>hda-2<\/jats:italic>\n            backgrounds, we evaluate the role of HDA-2 in the regulation of genes responsive to light and oxidative stress. \u0394\n            <jats:italic>hda-2<\/jats:italic>\n            strains present reduced growth, misregulation of the\n            <jats:italic>con-1<\/jats:italic>\n            gene, and absence of conidia in response to light and mechanical injury. We found that the expression of\n            <jats:italic>hda-2<\/jats:italic>\n            is BLR-1 dependent and HDA-2 in turn is essential for the transcription of early and late light-responsive genes that include\n            <jats:italic>blr-1<\/jats:italic>\n            , indicating a regulatory feedback loop. When subjected to reactive oxygen species (ROS), \u0394\n            <jats:italic>hda-2<\/jats:italic>\n            mutants display high sensitivity whereas \u0394\n            <jats:italic>blr<\/jats:italic>\n            strains exhibit the opposite phenotype. Consistently, in the presence of ROS, ROS-related genes show high transcription levels in wild-type and \u0394\n            <jats:italic>blr<\/jats:italic>\n            strains but misregulation in \u0394\n            <jats:italic>hda-2<\/jats:italic>\n            mutants. Finally, chromatin immunoprecipitations of histone H3 acetylated at Lys9\/Lys14 on\n            <jats:italic>cat-3<\/jats:italic>\n            and\n            <jats:italic>gst-1<\/jats:italic>\n            promoters display low accumulation of H3K9K14ac in \u0394\n            <jats:italic>blr<\/jats:italic>\n            and \u0394\n            <jats:italic>hda-2<\/jats:italic>\n            strains, suggesting indirect regulation of ROS-related genes by HDA-2. Our results point to a mutual dependence between HDA-2 and BLR proteins and reveal the role of these proteins in an intricate gene regulation landscape in response to blue light and ROS.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>IMPORTANCE<\/jats:bold>\n            <jats:named-content content-type=\"genus-species\">Trichoderma<\/jats:named-content>\n            <jats:italic>atroviride<\/jats:italic>\n            is a free-living fungus commonly found in soil or colonizing plant roots and is widely used as an agent in biocontrol as it parasitizes other fungi, stimulates plant growth, and induces the plant defense system. To survive in various environments, fungi constantly sense and respond to potentially threatening external factors, such as light. In particular, UV light can damage biomolecules by producing free-radical reactions, in most cases involving reactive oxygen species (ROS). In\n            <jats:named-content content-type=\"genus-species\">T. atroviride<\/jats:named-content>\n            , conidiation is essential for its survival, which is induced by light and mechanical injury. Notably, conidia are typically used as the inoculum in the field during biocontrol. Therefore, understanding the linkages between responses to light and exposure to ROS in\n            <jats:named-content content-type=\"genus-species\">T. atroviride<\/jats:named-content>\n            is of major basic and practical relevance. Here, the histone deacetylase-encoding gene\n            <jats:italic>hda-2<\/jats:italic>\n            is induced by light and ROS, and its product regulates growth, conidiation, blue light perception, and oxidative stress responses.\n          <\/jats:p>","DOI":"10.1128\/aem.02922-16","type":"journal-article","created":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T03:25:36Z","timestamp":1479525936000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Histone Deacetylase HDA-2 Regulates Trichoderma atroviride Growth, Conidiation, Blue Light Perception, and Oxidative Stress Responses"],"prefix":"10.1128","volume":"83","author":[{"given":"Macario","family":"Osorio-Concepci\u00f3n","sequence":"first","affiliation":[{"name":"IPICYT, Divisi\u00f3n de Biolog\u00eda Molecular, San Luis Potos\u00ed, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema Rosa","family":"Crist\u00f3bal-Mondrag\u00f3n","sequence":"additional","affiliation":[{"name":"IPICYT, Divisi\u00f3n de Biolog\u00eda Molecular, San Luis Potos\u00ed, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braulio","family":"Guti\u00e9rrez-Medina","sequence":"additional","affiliation":[{"name":"IPICYT, Divisi\u00f3n de Materiales Avanzados, San Luis Potos\u00ed, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Casas-Flores","sequence":"additional","affiliation":[{"name":"IPICYT, Divisi\u00f3n de Biolog\u00eda Molecular, San Luis Potos\u00ed, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.112408.134000"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1079\/9781780642475.0043","volume-title":"Trichoderma: biology and applications","author":"Casas-Flores S","year":"2013","unstructured":"Casas-Flores S Herrera-EstrellaA. 2013. 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